Figure 33

Comparison of our results with the most commonly held view of the anatomical locations of neurogenic niches in the temporal lobe. This figure shows an antero-medial view of the medial temporal lobe in a coronal cut at the junction of the head and body of the hippocampus. The zones currently regarded as neurogenic niches are identified by black lines. The blue dotted lines represent the NPCL in the hippocampus, which occupies the SVZ of the collateral eminence (b) and the SVZ of the hippocampus (a). From the fimbria ((3) and arrowhead), the NPCL forms two branches that run to the SGZ (c) and to the depth of the hippocampal sulcus (6). The red dotted line illustrates that the primary location of DCX staining in the hippocampal formation coincides with its efferent pathway in the portion from the subiculum (8) to the fimbria. This pathway includes an extraventricular subependymal zone that displays the color of the gray matter (the line between the arrows in the inlet). 1, collateral eminence; 2, body of the hippocampus; 4, fimbriodentate sulcus; 5, dentate gyrus (margo denticulatus); 7, parahippocampal gyrus (medial surface) (macroscopic anatomy); 9, entorhinal cortex (the presubiculum and parasubiculum are located between 8 and 9); 10, parahippocampus (cytoarchitecture); 11, parahippocampal gyrus (coronal cut) (macroscopic anatomy); 12, uncus.