Figure 2From: The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas Immunohistochemical analysis of Smad3 and p-Smad3. (A) Low Smad3 expression in invasive NFPA (case 1). (B) High Smad3 expression in noninvasive NFPA (case 2). (C) Low p-Smad3 expression in invasive NFPA (case 1). (D) High p-Smad3 expression in noninvasive NFPA (case 2). (E and F) The staining scores of Smad3 and p-Smad3. Magnification: 400×. **, P < 0.01.Back to article page