Figure 9
From: Regulatory mechanisms of betacellulin in CXCL8 production from lung cancer cells
Proposed mechanism of BTC-stimulated IL-8 production and bio-behaviors of lung cancer cells. BTC could directly stimulate IL-8 production and bio-behaviors of lung cancer cells through the activation of EGFR, PI3K/Akt, and Erk signal pathway, then lead to the recruitment of inflammatory cells in the cancer tissue and the formation of inflammatory microenvironment. This has been highlighted as an important factor responsible for the sensitivity of human lung cancer to therapies and prognosis of patients.