Figure 4
From: Regulatory mechanisms of betacellulin in CXCL8 production from lung cancer cells
Treatment with PI3K inhibitors, Erk1/2 inhibitor or Erlotinib significantly inhibited BTC-induced IL-8 production in A549 lung cancer cells. IL-8 production from cells was measured 24 h after the culture with DMSO alone, BTC at 0.1ug/ml plus DMSO, BEZ235 (BEZ; A), GDC0941 (GDC; B), SHBM1009 (SHBM; C) or Erlotinib (TKI; D), PD98059 (PD; E) at doses of 0.1, 1.0 or 10 μM. * and ** stand for P- values less than 0.05 and 0.01 as compared to cells only with DMSO, and + and ++ stand for P-values less than 0.05 and 0.01, as compared to BTC and DMSO, respectively. Data is presented as mean ± SEM and each group has six measurements.