The clinical significance of tumor-infiltrating neutrophils and neutrophil-to-CD8+ lymphocyte ratio in patients with resectable esophageal squamous cell carcinoma

Table 2 Correlation of peritumoral CD66+ neutrophils, CD8+ lymphocytes and NLR with clinicopathological parameters

	Total	Peritumoral neutrophils^a			Peritumoral CD8+ lymphocytes^a			Peritumoral NLR
	90	Low	High	P value	Low	High	P value	<l	≥1	P value
Gender
Male	72	38	34	0.292	37	35	0.598	40	32	0.009
Female	18	7	11		8	10		16	2
Age	42-78
<60.5^b	45	25	20	0.292	25	20	0.292	27	18	0.664
≥60.5	45	20	25		20	25		29	16
Tumor location
Upper	10	6	4	0.612	6	4	0.769	6	4	0.634
Middle	48	25	23		24	24		28	20
Lower	32	14	18		15	17		22	10
Tumor length	0.5-8.5
<4.0^b	52	18	26	0.092	20	24	0.399	30	14	0.254
≥4.0	38	27	19		25	21		26	20
Differential grade
Well	25	9	16	0.185	14	11	0.764	12	13	0.221
Middle	39	20	19		19	20		26	13
Poor	26	16	10		12	14		18	8
T stage
1 and 2	31	18	13	0.267	12	19	0.12	27	4	<0.001
3 and 4	59	27	32		33	26		29	30
LN metastasis
Negative	57	27	30	0.512	26	31	0.274	40	17	0.041
Positive	33	18	15		19	14		16	17
Positive LN
0	57	27	30	0.764	26	31	0.045	40	17	0.014
1	12	7	5		10	2		3	9
≥2	21	11	10		9	12		13	8
pTNM stage
I	18	9	9	0.972	8	10	0.536	13	5	0.053
II	41	21	20		19	22		29	12
III	31	15	16		18	13		14	17
Recurrence
Yes	63	31	32	0.818	32	31	0.818	38	25	0.569
No	27	14	13		13	14		18	9

LN lymph node, pTNM pathological tumor node metastasis, NLR CD66+ neutrophil-to-CD8+ lymphocyte ratio, values in bold signify p < 0.05, ^aGrouped by median, ^bThe median.

ISSN: 1479-5876