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Table 3 Number of patients responded to each peptide

From: A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome

Dose of peptide (mg)

Patients

R

T

K

R1

R2

Total

Average*

n

Within 3 courses of vaccinations

 

0.5

3

2

0

1

1

2

6

2.0

1

3

2

2

1

1

1

7

2.3

3

6

3

4

5

4

3

19

3.2**

3 (cocktail)

6

5

3

4

4

5

21

3.5**

  1. R: RNF43, T: TOMM34, K: KOC1, R1: VEGFR1, R2: VEGFR2.
  2. *: The average numbers of specific CTL induction against each of five peptides per each patient.
  3. **: There was no significant difference to induce the immune responses between the multiple injections of “each peptide” and the single injection of “the peptide cocktail”. (p=0.694, t-test).