|
Dose of peptide (mg)
|
Patients
|
R
|
T
|
K
|
R1
|
R2
|
Total
|
Average*
|
|---|
|
n
|
Within 3 courses of vaccinations
| |
|---|
|
0.5
|
3
|
2
|
0
|
1
|
1
|
2
|
6
|
2.0
|
|
1
|
3
|
2
|
2
|
1
|
1
|
1
|
7
|
2.3
|
|
3
|
6
|
3
|
4
|
5
|
4
|
3
|
19
|
3.2**
|
|
3 (cocktail)
|
6
|
5
|
3
|
4
|
4
|
5
|
21
|
3.5**
|
- R: RNF43, T: TOMM34, K: KOC1, R1: VEGFR1, R2: VEGFR2.
- *: The average numbers of specific CTL induction against each of five peptides per each patient.
- **: There was no significant difference to induce the immune responses between the multiple injections of “each peptide” and the single injection of “the peptide cocktail”. (p=0.694, t-test).
