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Table 3 Number of patients responded to each peptide

From: A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome

Dose of peptide (mg) Patients R T K R1 R2 Total Average*
n Within 3 courses of vaccinations  
0.5 3 2 0 1 1 2 6 2.0
1 3 2 2 1 1 1 7 2.3
3 6 3 4 5 4 3 19 3.2**
3 (cocktail) 6 5 3 4 4 5 21 3.5**
  1. R: RNF43, T: TOMM34, K: KOC1, R1: VEGFR1, R2: VEGFR2.
  2. *: The average numbers of specific CTL induction against each of five peptides per each patient.
  3. **: There was no significant difference to induce the immune responses between the multiple injections of “each peptide” and the single injection of “the peptide cocktail”. (p=0.694, t-test).