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Table 2 Patients characteristics and outcomes

From: A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome

Case Dose of peptide (mg) Age Sex PS Site of desease Previous treatment* IFN γ response to each peptide Number of vaccination Period of vaccinations (days) Toxicity Response Prognosis (days) Treatments after vaccination
R T K R1 R2 Injection site reaction General PFS OS
Pre vaccinations
Within 3 courses of vaccinations
Within 6 courses of vaccinations
1 0.5 56 M 0 LN IRI, OX, FU ++ 85 2150 2 None CR 2150 2150 A None
+ ++
+ ++ + ++
2 0.5 72 F 1 Lung, bone IRI, OX, FU 16 120 1 None PD 60 191 D None
+ +
+ + +
3 0.5 75 M 1 Liver, lung IRI, OX, FU ++ 27 364 1 None SD 158 406 D OX, FU, BEV
++ +
++ + +
4 1 59 F 2 Dissemi. IRI, OX, FU 8 49 1 None PD 36 80 D None
++
++ + +
5 1 68 M 0 Lung IRI, OX, FU 25 329 2 None PD 68 1009 D OX, FU, IRI, BEV, CETU
++ + ++ + ++
++ + ++ + ++
6 1 69 M 2 Lung, LN IRI, OX, FU + 13 84 2 None PD 62 110 D None
++
++
8 3 85 F 1 Dissemi. FU 11 70 2 None PD 103 461 D IRI, FU
+
+
9 3 59 M 0 Lung IRI, OX, FU + 45 777 2 None SD 221 885 D None
++ ++ ++ ++
++ ++ ++ ++
10 3 49 F 0 Liver, lung IRI, FU ++ 39 777 2 Fever <38.0°C PD 69 834 D OX, FU, IRI, BEV
+++ ++ ++ +
+++ ++ ++ +
11 3 46 F 0 Lung none 13 64 2 Erythena (G1) SD 117 1029 D OX, FU, IRI, BEV
+ ++ +++ ++
+ ++ +++ ++
12 3 71 M 0 Local OX, FU 63 959 2 None SD 120 1059 D IRI, FU, OX, BEV
+ ++ ++ +
+ ++ ++ + +
13 3 71 M 2 Liver, lung, bone IRI, OX, FU, RAD 8 49 1 None PD 57 133 D None
++ ++
++ ++
14 3 (mix) 65 F 2 Dissemi. IRI, OX, FU 8 49 1 None PD 50 342 D None
+ + ++ + ++
+ + ++ + ++
15 3 (mix) 71 M 2 Liver, lung IRI, OX, FU 8 49 1 None PD 36 102 D None
+ +++ ++
+ +++ ++
16 3 (mix) 57 M 1 Local none ++ 38 749 2 None SD 771 1161 D None
+ +++ +++
+ ++ +++ +++
17 3 (mix) 65 M 1 Dissemi. OX, FU + +++ 16 126 2 None PD 69 145 D None
+ + + +++ +
+ + + +++ +
18 3 (mix) 55 F 0 Local IRI, FU + + 8 49 2 None SD 56 56 A Curative resection
+
+
19 3 (mix) 58 F 2 Liver, Dissemi. OX, FU, BEV ++ + + 8 49 1 None PD 37 52 D None
++ + ++ +
++ + ++ +
  1. PS: Eastern Cooperative Oncology Group performance status, LN: lymph nodes, Dessemi: peritoneal dissemination, PFS: progression free survival, OS: over all survival.
  2. IRI: irinotican, OX: oxaliplatin, FU: fluoropyrimidine, RAD: radiation, BEV: bevacizumab, CETU: cetuximab, R: RNF43, T: TOMM34, K: KOC1, R1: VEGFR1, R2: VEGFR2, D: daed, A: alive.
  3. CR:complete response, PR: partial response, SD: stable desease, PD: progression desease, *: operation was performed for all patients for the resection of primary lesions.