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Table 1 Binding score of each peptide

From: A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome

Epitope peptides

Sequence

Binding score* to HLA-A*24:02

Expression in colorectal cancer (%)

Remarks on function and tumor relevance

References

RNF43 - 721

NSQPVWLCL

10

90%

Growth of cancer cells

[4, 17]

TOMM34 - 299

KLRQEVKQNL

13.4

80%

Growth of cancer cells

[5]

KOC1 - 508

KTVNELQNL

14.4

77%

Metastasis and invasion

[6, 7, 18]

VEGFR1 - 1084

SYGVLLWEI

66

100%**

Tumor angiogenesis,growth through autocrine

[14, 15, 19, 20]

VEGFR2 - 169

RFVPDGNRI

22

  1. *The binding affinities were estimated using the BioInformatics and Molecular Analysis Section websites.
  2. **100% in tumor cells as well as tumor associated neovascularity.