A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome

Table 1 Binding score of each peptide

Epitope peptides	Sequence	Binding score* to HLA-A*24:02	Expression in colorectal cancer (%)	Remarks on function and tumor relevance	References
RNF43 - 721	NSQPVWLCL	10	90%	Growth of cancer cells	[4, 17]
TOMM34 - 299	KLRQEVKQNL	13.4	80%	Growth of cancer cells	[5]
KOC1 - 508	KTVNELQNL	14.4	77%	Metastasis and invasion	[6, 7, 18]
VEGFR1 - 1084	SYGVLLWEI	66	100%**	Tumor angiogenesis,growth through autocrine	[14, 15, 19, 20]
VEGFR2 - 169	RFVPDGNRI	22	100%**	Tumor angiogenesis,growth through autocrine	[14, 15, 19, 20]

*The binding affinities were estimated using the BioInformatics and Molecular Analysis Section websites.
**100% in tumor cells as well as tumor associated neovascularity.