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Table 1 Binding score of each peptide

From: A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome

Epitope peptides Sequence Binding score* to HLA-A*24:02 Expression in colorectal cancer (%) Remarks on function and tumor relevance References
RNF43 - 721 NSQPVWLCL 10 90% Growth of cancer cells [4, 17]
TOMM34 - 299 KLRQEVKQNL 13.4 80% Growth of cancer cells [5]
KOC1 - 508 KTVNELQNL 14.4 77% Metastasis and invasion [6, 7, 18]
VEGFR1 - 1084 SYGVLLWEI 66 100%** Tumor angiogenesis,growth through autocrine [14, 15, 19, 20]
VEGFR2 - 169 RFVPDGNRI 22
  1. *The binding affinities were estimated using the BioInformatics and Molecular Analysis Section websites.
  2. **100% in tumor cells as well as tumor associated neovascularity.
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