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Table 3 The differentially expressed proteins identified in CD4 + T cells between active VKH patients and normal individuals

From: Proteomic profiling of lymphocytes in autoimmunity, inflammation and cancer

Identified proteins

Expression

Number of peptides

Function

Integrin β

Up-regulated

Singe

Protein binding

Coronin-2A

Up-regulated

Singe

Protein binding

C19orf2 protein

Up-regulated

Singe

Protein binding

Isoform 4 of Dystrophin

Up-regulated

Singe

Structural constitute of cytoskeleton, muscle; protein, calcium ion, actin, zinc ion binding

Synaptonemal complex protein 2

Up-regulated

Singe

DNA binding

Hypothetical protein LOC345651

Up-regulated

Singe

Protein binding

Isoform 1 of Solute carrier family 22 member 11

Up-regulated

Singe

Sodium-independent organic anion transporter activity

UBC; UBB ubiquitin and ribosomal protein S27a precursor

Up-regulated

Singe

Structural constituent of ribosome

PRA1 family protein 3

Up-regulated

Singe

Protein binding

Actin, cytoplasmic 1

Up-regulated

Singe

Structural constituent of cytoskeleton; protein, ATP, nucleotide binding

Probable G-protein coupled receptor 179 precursor

Up-regulated

Singe

Metabotropic glutamate, GABA-B-like receptor activity

Heat shock 70 kDa protein 9, mitochondrial precursor

Up-regulated

Singe

Unfolded protein binding; ATP, nucleotide binding

ELMO2 protein

Up-regulated

Singe

Binding

Isoform 1 of Peripherin

Down-regulated

Singe

Structural molecule activity

ATP synthase subunit α, mitochondrial precursor

Down-regulated

Singe

Protein, ATP, nucleotide, metal ion binding; hydrogen-transporting ATPase/ATP synthase activity; hydrolase, transporter activity

Calnexin precursor

Down-regulated

Singe

Calcium ion, sugar binding; unfolded protein binding

Integrin β-2 precursor

Down-regulated

Singe

Protein, protein kinase binding; receptor activity

Vimentin

Up-regulated

Two or more

Structural constituent of cytoskeleton; protein binding; structural molecule activity; oxygen transporter activity

Keratin, type I cytoskeletal 10

Up-regulated

Two or more

Structural constituent of epidermis; structural molecule activity

ATP synthase subunit β, mitochondrial precursor

Up-regulated

Two or more

Protein, ATP, nucleotide, metal ion binding; hydrogen-transporting ATPase/ATP synthase activity; hydrolase, transporter activity; hydrogen-exporting ATPase activity; nucleotide-triphosphatase activity

Actin, aortic smooth muscle

Up-regulated

Two or more

Structural constituent of cytoskeleton; protein, ATP, nucleotide binding

Keratin, type II cytoskeletal 1

Up-regulated

Two or more

Structural constituent of cytoskeleton; protein, sugar binding; receptor activity

Uncharacterized protein ALB

Up-regulated

Two or more

Protein, water, toxin, pyridoxal phosphate, drug, fatty acid, oxygen, copper ion, DNA, metal ion binding; carrier, antioxidant activity

Isoform ASF-1 of Splicing factor, arginine/serine-rich 1

Down-regulated

Two or more

Protein, nucleotide, RNA binding