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Table 3 The differentially expressed proteins identified in CD4 + T cells between active VKH patients and normal individuals

From: Proteomic profiling of lymphocytes in autoimmunity, inflammation and cancer

Identified proteins Expression Number of peptides Function
Integrin β Up-regulated Singe Protein binding
Coronin-2A Up-regulated Singe Protein binding
C19orf2 protein Up-regulated Singe Protein binding
Isoform 4 of Dystrophin Up-regulated Singe Structural constitute of cytoskeleton, muscle; protein, calcium ion, actin, zinc ion binding
Synaptonemal complex protein 2 Up-regulated Singe DNA binding
Hypothetical protein LOC345651 Up-regulated Singe Protein binding
Isoform 1 of Solute carrier family 22 member 11 Up-regulated Singe Sodium-independent organic anion transporter activity
UBC; UBB ubiquitin and ribosomal protein S27a precursor Up-regulated Singe Structural constituent of ribosome
PRA1 family protein 3 Up-regulated Singe Protein binding
Actin, cytoplasmic 1 Up-regulated Singe Structural constituent of cytoskeleton; protein, ATP, nucleotide binding
Probable G-protein coupled receptor 179 precursor Up-regulated Singe Metabotropic glutamate, GABA-B-like receptor activity
Heat shock 70 kDa protein 9, mitochondrial precursor Up-regulated Singe Unfolded protein binding; ATP, nucleotide binding
ELMO2 protein Up-regulated Singe Binding
Isoform 1 of Peripherin Down-regulated Singe Structural molecule activity
ATP synthase subunit α, mitochondrial precursor Down-regulated Singe Protein, ATP, nucleotide, metal ion binding; hydrogen-transporting ATPase/ATP synthase activity; hydrolase, transporter activity
Calnexin precursor Down-regulated Singe Calcium ion, sugar binding; unfolded protein binding
Integrin β-2 precursor Down-regulated Singe Protein, protein kinase binding; receptor activity
Vimentin Up-regulated Two or more Structural constituent of cytoskeleton; protein binding; structural molecule activity; oxygen transporter activity
Keratin, type I cytoskeletal 10 Up-regulated Two or more Structural constituent of epidermis; structural molecule activity
ATP synthase subunit β, mitochondrial precursor Up-regulated Two or more Protein, ATP, nucleotide, metal ion binding; hydrogen-transporting ATPase/ATP synthase activity; hydrolase, transporter activity; hydrogen-exporting ATPase activity; nucleotide-triphosphatase activity
Actin, aortic smooth muscle Up-regulated Two or more Structural constituent of cytoskeleton; protein, ATP, nucleotide binding
Keratin, type II cytoskeletal 1 Up-regulated Two or more Structural constituent of cytoskeleton; protein, sugar binding; receptor activity
Uncharacterized protein ALB Up-regulated Two or more Protein, water, toxin, pyridoxal phosphate, drug, fatty acid, oxygen, copper ion, DNA, metal ion binding; carrier, antioxidant activity
Isoform ASF-1 of Splicing factor, arginine/serine-rich 1 Down-regulated Two or more Protein, nucleotide, RNA binding