Figure 5

Correlation of OVCAR3 and SKOV3 gene expression to patient tumors. A) Histograms of the correlation coefficients, calculated between every patient gene expression profile and cell line gene expression profiles, show that OVCAR3 expression following MSC coculture is negatively correlated with patient tumor expression while SKOV3 expression following MSC coculture is positively correlated. The OVCAR3 and SKOV3 random correlation distribution as shown by the random histograms indicates that the high positive and negative correlations are not due to chance. B) Scatterplots showing the p-value variation with the correlation coefficient indicates that the high and low correlations have significantly low p-values. P-value scatterplots of the random correlations also show higher p-values than the sample correlations indicating significant sample correlations.