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Table 5 Grade 3-4 vaccine-related toxicities

From: The immunological and clinical effects of mutated ras peptide vaccine in combination with IL-2, GM-CSF, or both in patients with solid tumors

Toxicity grade 3-4 Number of patients full cohort Number of patients arm A Number of patients arm B Number of patients arm C
Fatigue 3 2 0 1
Diarrhea 2 0 0 2
Vomiting 2 0 1 1
Increased transaminase 2 0 1 1
Local site reaction 1 0 1 0
Fever 1 0 0 1
Myalgia 1 0 0 1
Generalized rash 1 0 1 0
Myocardial infarction* 1 1 0 0
  1. *Grade 4 Toxicity.
  2. All grade 3 toxicities were reported for the full cohort and per arm. Only one grade 4 toxicity of myocardial infarction was reported in one patient (3A).