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Table 5 Grade 3-4 vaccine-related toxicities

From: The immunological and clinical effects of mutated ras peptide vaccine in combination with IL-2, GM-CSF, or both in patients with solid tumors

Toxicity grade 3-4

Number of patients full cohort

Number of patients arm A

Number of patients arm B

Number of patients arm C

Fatigue

3

2

0

1

Diarrhea

2

0

0

2

Vomiting

2

0

1

1

Increased transaminase

2

0

1

1

Local site reaction

1

0

1

0

Fever

1

0

0

1

Myalgia

1

0

0

1

Generalized rash

1

0

1

0

Myocardial infarction*

1

1

0

0

  1. *Grade 4 Toxicity.
  2. All grade 3 toxicities were reported for the full cohort and per arm. Only one grade 4 toxicity of myocardial infarction was reported in one patient (3A).