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Table 1 Ras peptides used for vaccination

From: The immunological and clinical effects of mutated ras peptide vaccine in combination with IL-2, GM-CSF, or both in patients with solid tumors

Ras peptides Amino acid sequence Vaccinated patients by arm
  5  6  7  8  9  10  11 12 13 14 15 16  17  
ras 5-17 Lys- Leu-Val- Val- Val- Gly- Ala- Gly- Gly- Val- Gly- Lys- Ser Nome
(wild type)   
ras 5-17 Lys- Leu-Val- Val- Val- Gly- Ala- Asp- Gly- Val- Gly- Lys- Ser A: 1-4, 9-12, 14, 16
(Gly→Asp)   B: 3-6, 8-10, 14-16
   C: 1-5, 7, 9-11, 13-19
ras 5-17 Lys- Leu-Val- Val- Val- Gly- Ala- Val- Gly- Val- Gly- Lys- Ser A: 5, 6, 15
(Gly→Val)   B: 1, 7, 11, 12, 17, 18
   C: 6, 12
ras 5-17 Lys- Leu-Val- Val- Val- Gly- Ala- Cys- Gly- Val- Gly- Lys- Ser A: 7, 8, 13
(Gly→Cys)   B: 2, 13
   C: 8
  1. The peptides used in the study were 13-mer peptides (residues 5-17) corresponding to the tumor Ras mutations. Corresponding mutant part of the peptide is bolded.
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Journal of Translational Medicine

ISSN: 1479-5876

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