Skip to main content

Table 1 Biochemical and physical characteristics of the four groups at the end of the 4-week period

From: Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO-1 signaling

  VH (n = 6) VH + OA (n = 6) CsA (n = 6) CsA + OA (n = 8)
Body weight (g) 35.77 ± 5.25 34.3 ± 1.45 33.97 ± 2.34 32.78 ± 4.46
Kidney weight (g) 0.23 ± 0.04 0.23 ± 0.02 0.18 ± 0.04 0.22 ± 0.03
Urine volume (mL) 1.53 ± 0.97 2.53 ± 1.71 7.15 ± 5.15b 1.4 ± 1.96
Serum Cr (mg/dl) 0.21 ± 0.02 0.26 ± 0.02 0.30 ± 0.11 0.25 ± 0.06
Cr Clearance (mL/min/100 g BW) 0.72 ± 0.15 0.44 ± 0.09 0.26 ± 0.16a 0.52 ± 0.19
24 hr albuminuria (μg/day) 23.90 ± 4.48 26.75 ± 11.88 150.99 ± 57.42a 57.34 ± 7.44
Urine osmolality (mOsm/kg) 2088.67 ± 963.44 810.67 ± 181.88 582.00 ± 208.89b 2143.33 ± 547.01
CsA concentration (ng/mL) N/A N/A 1792.34 ± 63.08 1764.40 ± 28.56
  1. Data are means ± SEM. ap < 0.05 compared with vehicle, bp < 0.05 compared with other groups. VH = vehicle-treated group; VH + OA = Vehicle plus oleanolic acid-treated group; CsA = cyclosporine-treated group; CsA + OA = cyclosporine plus oleanolic acid-treated group; Cr = creatinine; BW = body weight; N/A = not available.