Plasminogen initiates and potentiates the healing of acute and chronic tympanic membrane perforations in mice

Table 4 IHC analysis of subcutaneous or intraperitoneal plg injection treatment for TM perforations in plg ^-/- mice

Treatment group	Healed TM perforations/Total TM perforations
Subcutaneous PBS injection	0/8 (0%)
Subcutaneous plg injection	4/6 (67%)
P value	0.006285^$
Intraperitoneal PBS injection	0/8 (0%)
Intraperitoneal plg injection	6/6 (100%)
P value	0.000183^$$

Data were analyzed at day 9 after the perforations. The healing rate was calculated and is shown in parentheses. ^$ P < 0.05; ^$$ P < 0.001.

ISSN: 1479-5876