Skip to main content

Table 1 Dose-dependent healing effect of daily local plg injection in plg -/- mice

From: Plasminogen initiates and potentiates the healing of acute and chronic tympanic membrane perforations in mice

Treatment group

Healed TM perforations/Total TM perforations

Plg-/- mice

Group 1 (0.4 mg/day)

10/10 (100%)

Group 2 (0.2 mg/day)

10/10 (100%)

Group 3 (0.1 mg/day)

6/10 (60%)

Group 4 (PBS)

0/10 (0%)

WT mice (non-treated)

6/10 (60%)

  1. Data were analyzed by IHC staining at day 9 after the perforations. The healing rate was calculated and is shown in parentheses.