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Figure 2 | Journal of Translational Medicine

Figure 2

From: Plasminogen initiates and potentiates the healing of acute and chronic tympanic membrane perforations in mice

Figure 2

Characterization of the quality of TM healing in plg -/- mice treated locally with plg. (A) The scoring system used to evaluate the quality of healing of TM perforations. Scale bar, 400 μm. EEC, external ear canal; MEC, middle ear cavity; TM, tympanic membrane. (B) A comparison of quality of TM healing with the mean value marked by a line for mice from Group 1 (plg-/- mice injected with 0.4 mg/day of plg) (squares), Group 2 (plg-/- mice injected with 0.2 mg/day of plg) (open circles), Group 3 (plg-/- mice injected with 0.1 mg/day of plg) (triangles), non-treated WT control mice (diamonds), and Group 4 (plg-/- mice treated with PBS) (hexagons). The quality of healing was evaluated based on IHC keratin staining performed at day 9 after TM perforation. NS indicates not significant. P < 0.05 was considered to be significant.

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