Figure 2From: Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy? Proposed mode of action of milk miR-mediated demethylation of FOXP3 . Milk-derived miR-29b, -21, and -148a may reduce the expression of DNMTs resulting in TSDR hypomethylation required for IDAX binding, which finally attracts TET2 to the TSDR resulting in complete TSDR demethylation, important for permanent FOXP3 stabilization.Back to article page