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Table 1 Effects of TRO40303 on infarct size after cardiac ischemia reperfusion in rats

From: Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial

Dose (mg/kg) AAR (% LV) IS (% LV) IS (% AAR) IS (% Vehicle IS)
TRO40303 Vehicle TRO40303 Vehicle TRO40303 Vehicle TRO40303 Vehicle
0.3 45 ± 5 54 ± 4 11 ± 2 18 ± 3 26 ± 4 33 ± 4 77 ± 15 100 ± 13
1 39 ± 4 7 ± 1 19 ± 2 56 ± 6
3 43 ± 4 6 ± 1 15 ± 2 44 ± 7
10 30 ± 2 35 ± 3 7 ± 2 20 ± 3 25 ± 6 56 ± 6 45 ± 10 100 ± 10