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Table 1 Effects of TRO40303 on infarct size after cardiac ischemia reperfusion in rats

From: Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial

Dose (mg/kg)

AAR (% LV)

IS (% LV)

IS (% AAR)

IS (% Vehicle IS)

TRO40303

Vehicle

TRO40303

Vehicle

TRO40303

Vehicle

TRO40303

Vehicle

0.3

45 ± 5

54 ± 4

11 ± 2

18 ± 3

26 ± 4

33 ± 4

77 ± 15

100 ± 13

1

39 ± 4

7 ± 1

19 ± 2

56 ± 6

3

43 ± 4

6 ± 1

15 ± 2

44 ± 7

10

30 ± 2

35 ± 3

7 ± 2

20 ± 3

25 ± 6

56 ± 6

45 ± 10

100 ± 10

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Journal of Translational Medicine

ISSN: 1479-5876

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