Dose (mg/kg) | AAR (% LV) | IS (% LV) | IS (% AAR) | IS (% Vehicle IS) | ||||
---|---|---|---|---|---|---|---|---|
TRO40303 | Vehicle | TRO40303 | Vehicle | TRO40303 | Vehicle | TRO40303 | Vehicle | |
0.3 | 45 ± 5 | 54 ± 4 | 11 ± 2 | 18 ± 3 | 26 ± 4 | 33 ± 4 | 77 ± 15 | 100 ± 13 |
1 | 39 ± 4 | 7 ± 1 | 19 ± 2 | 56 ± 6 | ||||
3 | 43 ± 4 | 6 ± 1 | 15 ± 2 | 44 ± 7 | ||||
10 | 30 ± 2 | 35 ± 3 | 7 ± 2 | 20 ± 3 | 25 ± 6 | 56 ± 6 | 45 ± 10 | 100 ± 10 |