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Table 4 Median mRNA levels for 7 candidate genes in TOF cases and controls

From: Association of promoter methylation statuses of congenital heart defect candidate genes with Tetralogy of Fallot

Gene

Gene bank accession

Control, median (IQR), N

TOF, median (IQR), N

mRNA fold change

P value

EGFR

NM_201282

3.98 (1.84 – 6.93); N = 6

0.61 (0.46 – 0.75); N = 33

0.15

0.0003***

EVC2

NM_001166136

3.95 (1.50 – 6.21); N = 6

0.96 (0.79 – 1.56); N = 32

0.24

0.0033**

NFATC2

NM_001136021

7.72 (4.60 – 11.50); N = 6

1.39 (0.97 – 1.88); N = 41

0.18

0.0043**

NR2F2

NM_021005

3.27 (1.34 – 4.88); N = 6

1.12 (0.70 – 1.30); N = 41

0.34

0.0039**

TBX5

NM_080717

1.49 (1.35 – 4.42);N = 6

0.41 (0.19 – 0.67); N = 37

0.28

0.0013**

CFC1B

NM_001079530

2.20 (1.57 – 7.50); N = 6

0.66 (0.31 – 1.07); N = 39

0.30

0.0016**

GJA5

NM_005266

0.77 (0.34 – 1.06); N = 6

0.19 (0.16 – 0.32); N = 36

0.25

0.0053**

  1. **P < 0.01, ***P < 0.001 (Mann–Whitney test), IQR, Interquartile range.