Table 3 The median methylation values for 7 CHD candidate genes showing significant differences between TOF cases and controls
Gene | Gene bank accession | Gene amplicon | Control, median (IQR); N | TOF, median (IQR); N | P value | Position |
|---|---|---|---|---|---|---|
EGFR | NM_201282 | EGFR _M1 | 52.75(44.00-56.35);N = 6 | 60.50(56.10-68.08);N = 33 | 0.0042** | CpGI |
EVC2 | NM_001166136 | EVC2 _M1 | 29.63(18.84-32.25);N = 6 | 43.88(36.44-53.28);N = 32 | 0.0005*** | CpGI |
NFATC2 | NM_001136021 | NFATC2 _M2 | 21.80(17.50-25.53);N = 6 | 30.29(26.06-36.57);N = 41 | 0.0067** | CpGI |
NR2F2 | NM_021005 | NR2F2 | 62.50(54.35-68.30);N = 6 | 43.40(33.90-53.10);N = 41 | 0.0161* | CpGI shore |
TBX5 | NM_080717 | TBX5 _M1 | 42.04(32.97-54.69);N = 6 | 57.13(50.69-67.31);N = 37 | 0.0207* | CpGI shore |
CFC1B | NM_001079530 | CFC1B _M2 | 48.16(40.36-59.25);N = 6 | 63.50(53.57-80.60);N = 39 | 0.0178* | TSS |
GJA5 | NM_005266 | GJA5 | 32.83(29.00-36.08);N = 6 | 44.00(34.67-53.92);N = 36 | 0.0138* | TSS |