Figure 1

Median methylation levels in the promoter CpG islands of candidate genes of TOF cases and controls. (A) EGFR_ M1 median methylation level; (B) EVC2_ M1 median methylation level; (C) NFATC2_ M2 median methylation level. TSS, Transcription Start Sites; red vertical line, CpG sites; red thick bars, CpG islands; M, MassARRAY amplicon; The region between two arrows, target amplicon. *P < 0.05, **P < 0.01, ***P < 0.001 (Mann–Whitney test).