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Figure 5 | Journal of Translational Medicine

Figure 5

From: Association of cancer metabolism-related proteins with oral carcinogenesis – indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?

Figure 5

Immunohistochemical analysis and staining of LDHA in normal oral mucosal tissue, oral precursor lesions - hyperplasia, SIN I, SIN II, SIN III, and invasive OSCC. In comparison to normal tissue/hyperplasia a significantly (p < 0.05, Kruskal-Wallis Test; A and B) increased expression of LDHA is observed in OSCC. No difference of LDHA expression in OSCC is observed in comparison with SIN I-III (p = 0.0822, Mann–Whitney U Test). Analysis refers to averaged scores. Red line indicates LDHA expression results during carcinogenesis. Grey lines show 95% confidence intervals. Analysis of significant statistically different single values is indicated in the table below (B). SIN III is subdivided in severe dysplasia (sev. dysplasia) and carcinoma in situ (CIS). LDHA, lactate dehydrogenase; SIN, squamous intraepithelial neoplasia; N.T., normal tissue. Immunohistochemical staining shows representative images of LDHA expression in N.T. (C), SIN (D), and OSCC (E). Brown chromogen color (3,3′-Diaminobenzidine) indicates positive staining, the blue color shows the nuclear counterstaining by hematoxylin. The square box demonstrates the area of interest (original magnification: x100-fold, left panel) which is also shown in larger magnification (x200-fold, right panel).

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