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Table 4 Univariate analysis of predictors of SVR in g1 and g3 infected patients

From: In vitro blood cell responsiveness to IFN-α predicts clinical response independently of IL28B in hepatitis C virus genotype 1 infected patients

Genotype 1 infected patients SVR (n = 8) No SVR (n = 8) P value
Age (years -/+SD) 40.9 -/+4.2 47.3 -/+5.6 0.4
Sex (m/f) 6/2 4/4 0.61§
IL28B genotype (CC/CT or TT)* 5/3 5/1 0.58§
Fibrosis 2.5 -/+0.9 1.7 -/+0.6 0.59
RVR (Y/N) 4/4 2/6 0.61§
Viral load (x106) 2.1 -/+1.1 5.6 -/+3.1 0.65
Liver enzyme levels    
ALT 87 -/+26.6 44.1 -/+8.6 0.57
AST 162.3 -/+58.2 53.3 -/+8.9 0.19
Leukocyte counts    
White cell count 5.6 -/+1 5.9 -/+0.5 0.56
Neutrophils 3.2 -/+0.7 3.3 -/+0.4 0.8
Lymphocytes 1.8 -/+0.3 1.9 -/+0.2 0.68
Monocytes 0.5 -/+0.1 0.4 -/+0.05 0.72
ISG expression    
PKR endogenous 3.3 -/+1.1 0.7 -/+0.1 0.028
OAS endogenous 2.6 -/+0.8 0.7 -/+0.2 0.19
MxA endogenous 8.1 -/+3.2 1.3 -/+0.5 0.021
PKR induction 41.1 -/+9.2 10.8 -/+2.8 0.015
OAS induction 51 -/+19.3 8.8 -/+3.4 0.002
MxA induction 235 -/+52.5 29.7 -/+10.6 0.002
Genotype 3 infected patients SVR (n = 13) No SVR (n = 7) P value
Age (years -/+SD) 39.6 -/+1.9 47 -/+2.4 0.03
Sex (m/f) 7/6 5/2 0.64§
IL28B genotype (CC/CT or TT)* 4/5 4/3 1§
RVR (Y/N) 10/3 2/5 0.06 §
Viral load (x106) 7.8 -/+3.8 9.6 -/+3.6 0.045
Liver enzyme levels    
ALT 93 -/+17 147 -/+38 0.24
AST 58.2 -/+9.8 109 -/+25.6 0.13
Leukocyte counts    
White cell count 6.6 -/+0.7 5.8 -/+0.8 0.37
Neutrophils 3 -/+0.5 3.1 -/+0.5 0.76
Lymphocytes 2.7 -/+0.3 1.9 -/+0.2 0.07
Monocytes 0.6 -/+0.1 0.5 -/+0.1 0.71
ISG expression    
PKR endogenous 2.1 -/+0.5 2 -/+1 0.81
OAS endogenous 2.2 -/+1 2 -/+0.6 0.31
MxA endogenous 11.4 -/+4.4 8.1 -/+3.2 0.57
PKR induction 29.1 -/+6.9 29.5 -/+9.6 0.93
OAS induction 23.9 -/+8 70.6 -/+36.8 0.48
MxA induction 126 -/+34 226.4 -/+81.2 0.21
  1. RVR rapid virological response, ALT alanine aminotrasferase, AST aspartate aminotransferase.
  2. *Data not available for all patients included in study.
  3. §Fisher’s exact test.
  4. Mann–Whitney U test.