Table 4 Univariate analysis of predictors of SVR in g1 and g3 infected patients
Genotype 1 infected patients | SVR (n = 8) | No SVR (n = 8) | P value |
|---|---|---|---|
Age (years -/+SD) | 40.9 -/+4.2 | 47.3 -/+5.6 | 0.4¶ |
Sex (m/f) | 6/2 | 4/4 | 0.61§ |
IL28B genotype (CC/CT or TT)* | 5/3 | 5/1 | 0.58§ |
Fibrosis | 2.5 -/+0.9 | 1.7 -/+0.6 | 0.59¶ |
RVR (Y/N) | 4/4 | 2/6 | 0.61§ |
Viral load (x106) | 2.1 -/+1.1 | 5.6 -/+3.1 | 0.65¶ |
Liver enzyme levels | |||
ALT | 87 -/+26.6 | 44.1 -/+8.6 | 0.57¶ |
AST | 162.3 -/+58.2 | 53.3 -/+8.9 | 0.19¶ |
Leukocyte counts | |||
White cell count | 5.6 -/+1 | 5.9 -/+0.5 | 0.56¶ |
Neutrophils | 3.2 -/+0.7 | 3.3 -/+0.4 | 0.8¶ |
Lymphocytes | 1.8 -/+0.3 | 1.9 -/+0.2 | 0.68¶ |
Monocytes | 0.5 -/+0.1 | 0.4 -/+0.05 | 0.72¶ |
ISG expression | |||
PKR endogenous | 3.3 -/+1.1 | 0.7 -/+0.1 | 0.028 ¶ |
OAS endogenous | 2.6 -/+0.8 | 0.7 -/+0.2 | 0.19¶ |
MxA endogenous | 8.1 -/+3.2 | 1.3 -/+0.5 | 0.021 ¶ |
PKR induction | 41.1 -/+9.2 | 10.8 -/+2.8 | 0.015 ¶ |
OAS induction | 51 -/+19.3 | 8.8 -/+3.4 | 0.002 ¶ |
MxA induction | 235 -/+52.5 | 29.7 -/+10.6 | 0.002 ¶ |
Genotype 3 infected patients | SVR (n = 13) | No SVR (n = 7) | P value |
Age (years -/+SD) | 39.6 -/+1.9 | 47 -/+2.4 | 0.03 ¶ |
Sex (m/f) | 7/6 | 5/2 | 0.64§ |
IL28B genotype (CC/CT or TT)* | 4/5 | 4/3 | 1§ |
RVR (Y/N) | 10/3 | 2/5 | 0.06 § |
Viral load (x106) | 7.8 -/+3.8 | 9.6 -/+3.6 | 0.045 ¶ |
Liver enzyme levels | |||
ALT | 93 -/+17 | 147 -/+38 | 0.24¶ |
AST | 58.2 -/+9.8 | 109 -/+25.6 | 0.13¶ |
Leukocyte counts | |||
White cell count | 6.6 -/+0.7 | 5.8 -/+0.8 | 0.37¶ |
Neutrophils | 3 -/+0.5 | 3.1 -/+0.5 | 0.76¶ |
Lymphocytes | 2.7 -/+0.3 | 1.9 -/+0.2 | 0.07¶ |
Monocytes | 0.6 -/+0.1 | 0.5 -/+0.1 | 0.71¶ |
ISG expression | |||
PKR endogenous | 2.1 -/+0.5 | 2 -/+1 | 0.81¶ |
OAS endogenous | 2.2 -/+1 | 2 -/+0.6 | 0.31¶ |
MxA endogenous | 11.4 -/+4.4 | 8.1 -/+3.2 | 0.57¶ |
PKR induction | 29.1 -/+6.9 | 29.5 -/+9.6 | 0.93¶ |
OAS induction | 23.9 -/+8 | 70.6 -/+36.8 | 0.48¶ |
MxA induction | 126 -/+34 | 226.4 -/+81.2 | 0.21¶ |