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Table 1 Common proteins identified in exosomes isolated from fresh plasma and after freeze/thawing cycles

From: Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy

Protein ID

Symbol

Entrez gene name

Location

Type(s)

A2MG_HUMAN

A2M

alpha-2-macroglobulin

Extracellular Space

transporter

A2ML1_HUMAN

A2ML1

alpha-2-macroglobulin-like 1

Cytoplasm

other

ACACA_HUMAN

ACACA

acetyl-CoA carboxylase alpha

Cytoplasm

enzyme

ACTN3_HUMAN

ACTN3

actinin, alpha 3

Plasma Membrane

other

ADAL_HUMAN

ADAL

adenosine deaminase-like

Cytoplasm

enzyme

ATS16_HUMAN

ADAMTS16

ADAM metallopeptidase with thrombospondin type 1 motif, 16

Extracellular Space

other

ATS9_HUMAN

ADAMTS9

ADAM metallopeptidase with thrombospondin type 1 motif, 9

Extracellular Space

peptidase

DSRAD_HUMAN

ADAR

adenosine deaminase, RNA-specific

Nucleus

enzyme

ADCY7_HUMAN

ADCY7

adenylate cyclase 7

Plasma Membrane

enzyme

KFA_HUMAN

AFMID

arylformamidase

Nucleus

enzyme

ANGT_HUMAN

AGT

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Extracellular Space

growth factor

ALBU_HUMAN

ALB

albumin

Extracellular Space

transporter

AMZ1_HUMAN

AMZ1

archaelysin family metallopeptidase 1

Other

peptidase

ANK2_HUMAN

ANK2

ankyrin 2, neuronal

Plasma Membrane

other

ANKAR_HUMAN

ANKAR

ankyrin and armadillo repeat containing

Nucleus

transcription regulator

AKD1B_HUMAN

ANKDD1B

ankyrin repeat and death domain containing 1B

Other

other

ANKL1_HUMAN

ANKLE1

ankyrin repeat and LEM domain containing 1

Other

other

ANR12_HUMAN

ANKRD12

ankyrin repeat domain 12

Nucleus

other

ANR26_HUMAN

ANKRD26

ankyrin repeat domain 26

Nucleus

transcription regulator

ANKUB_HUMAN

ANKUB1

ankyrin repeat and ubiquitin domain containing 1

Other

other

APOA1_HUMAN

APOA1

apolipoprotein A-I

Extracellular Space

transporter

APOB_HUMAN

APOB

apolipoprotein B

Extracellular Space

transporter

APOL1_HUMAN

APOL1

apolipoprotein L, 1

Extracellular Space

transporter

APOP1_HUMAN

APOPT1

apoptogenic 1, mitochondrial

Cytoplasm

other

DP13B_HUMAN

APPL2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

Cytoplasm

other

RHG15_HUMAN

ARHGAP15

Rho GTPase activating protein 15

Cytoplasm

other

RHG08_HUMAN

ARHGAP8/PRR5-ARHGAP8

Rho GTPase activating protein 8

Cytoplasm

other

ARHGB_HUMAN

ARHGEF11

Rho guanine nucleotide exchange factor (GEF) 11

Cytoplasm

other

ASPM_HUMAN

ASPM

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

Nucleus

other

ATG2B_HUMAN

ATG2B

autophagy related 2B

Other

other

AT2A3_HUMAN

ATP2A3

ATPase, Ca++ transporting, ubiquitous

Cytoplasm

transporter

RENR_HUMAN

ATP6AP2

ATPase, H + transporting, lysosomal accessory protein 2

Cytoplasm

transporter

ATR_HUMAN

ATR

ataxia telangiectasia and Rad3 related

Nucleus

kinase

B4GT7_HUMAN

B4GALT7

xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7

Cytoplasm

enzyme

BEND4_HUMAN

BEND4

BEN domain containing 4

Other

other

OSTCN_HUMAN

BGLAP

bone gamma-carboxyglutamate (gla) protein

Extracellular Space

other

BLM_HUMAN

BLM

Bloom syndrome, RecQ helicase-like

Nucleus

enzyme

BRCA2_HUMAN

BRCA2

breast cancer 2, early onset

Nucleus

transcription regulator

BRPF1_HUMAN

BRPF1

bromodomain and PHD finger containing, 1

Nucleus

transporter

CS068_HUMAN

C19orf68

chromosome 19 open reading frame 68

Other

other

CA174_HUMAN

C1orf174

chromosome 1 open reading frame 174

Nucleus

other

CA228_HUMAN

C1orf228

chromosome 1 open reading frame 228

Other

other

C1QC_HUMAN

C1QC

complement component 1, q subcomponent, C chain

Extracellular Space

other

CO3_HUMAN

C3

complement component 3

Extracellular Space

peptidase

CO4A_HUMAN

C4A/C4B

complement component 4B (Chido blood group)

Extracellular Space

other

C4BPA_HUMAN

C4BPA

complement component 4 binding protein, alpha

Extracellular Space

other

CI078_HUMAN

C9orf78

chromosome 9 open reading frame 78

Other

other

CAH3_HUMAN

CA3

carbonic anhydrase III, muscle specific

Cytoplasm

enzyme

CABIN_HUMAN

CABIN1

calcineurin binding protein 1

Nucleus

other

CAND1_HUMAN

CAND1

cullin-associated and neddylation-dissociated 1

Cytoplasm

transcription regulator

CAN1_HUMAN

CAPN1

calpain 1, (mu/I) large subunit

Cytoplasm

peptidase

CAN2_HUMAN

CAPN2

calpain 2, (m/II) large subunit

Cytoplasm

peptidase

CASC5_HUMAN

CASC5

cancer susceptibility candidate 5

Nucleus

other

C8AP2_HUMAN

CASP8AP2

caspase 8 associated protein 2

Nucleus

transcription regulator

CC154_HUMAN

CCDC154

coiled-coil domain containing 154

Other

other

CC171_HUMAN

CCDC171

coiled-coil domain containing 171

Other

other

CCD30_HUMAN

CCDC30

coiled-coil domain containing 30

Other

other

CCD37_HUMAN

CCDC37

coiled-coil domain containing 37

Other

other

CCD80_HUMAN

CCDC80

coiled-coil domain containing 80

Nucleus

other

CCHCR_HUMAN

CCHCR1

coiled-coil alpha-helical rod protein 1

Cytoplasm

other

CENPH_HUMAN

CENPH

centromere protein H

Nucleus

other

CP135_HUMAN

CEP135

centrosomal protein 135 kDa

Cytoplasm

other

CFAH_HUMAN

CFH

complement factor H

Extracellular Space

other

CHD4_HUMAN

CHD4

chromodomain helicase DNA binding protein 4

Nucleus

enzyme

CHD9_HUMAN

CHD9

chromodomain helicase DNA binding protein 9

Cytoplasm

other

ACHG_HUMAN

CHRNG

cholinergic receptor, nicotinic, gamma (muscle)

Plasma Membrane

transmembrane receptor

CHSTB_HUMAN

CHST11

carbohydrate (chondroitin 4) sulfotransferase 11

Cytoplasm

enzyme

CHSS3_HUMAN

CHSY3

chondroitin sulfate synthase 3

Cytoplasm

enzyme

CILP1_HUMAN

CILP

cartilage intermediate layer protein, nucleotide pyrophosphohydrolase

Extracellular Space

phosphatase

CLNK_HUMAN

CLNK

cytokine-dependent hematopoietic cell linker

Cytoplasm

other

CLUS_HUMAN

CLU

clusterin

Cytoplasm

other

CMBL_HUMAN

CMBL

carboxymethylenebutenolidase homolog (Pseudomonas)

Cytoplasm

enzyme

CNO6L_HUMAN

CNOT6L

CCR4-NOT transcription complex, subunit 6-like

Cytoplasm

enzyme

COPA1_HUMAN

COL25A1

collagen, type XXV, alpha 1

Cytoplasm

other

CROCC_HUMAN

CROCC

ciliary rootlet coiled-coil, rootletin

Plasma Membrane

other

CSRN1_HUMAN

CSRNP1

cysteine-serine-rich nuclear protein 1

Nucleus

transcription regulator

DIAC_HUMAN

CTBS

chitobiase, di-N-acetyl-

Cytoplasm

enzyme

CUL9_HUMAN

CUL9

cullin 9

Cytoplasm

other

CWC25_HUMAN

CWC25

CWC25 spliceosome-associated protein homolog (S. cerevisiae)

Other

other

CP1A2_HUMAN

CYP1A2

cytochrome P450, family 1, subfamily A, polypeptide 2

Cytoplasm

enzyme

CP51A_HUMAN

CYP51A1

cytochrome P450, family 51, subfamily A, polypeptide 1

Cytoplasm

enzyme

DAPL1_HUMAN

DAPL1

death associated protein-like 1

Other

other

DCAF6_HUMAN

DCAF6

DDB1 and CUL4 associated factor 6

Nucleus

transcription regulator

DCR1B_HUMAN

DCLRE1B

DNA cross-link repair 1B

Nucleus

enzyme

DCSTP_HUMAN

DCSTAMP

dendrocyte expressed seven transmembrane protein

Plasma Membrane

other

DCX_HUMAN

DCX

doublecortin

Cytoplasm

other

DDX51_HUMAN

DDX51

DEAD (Asp-Glu-Ala-Asp) box polypeptide 51

Other

enzyme

DEN2D_HUMAN

DENND2D

DENN/MADD domain containing 2D

Cytoplasm

other

DESM_HUMAN

DES

desmin

Cytoplasm

other

DGAT1_HUMAN

DGAT1

diacylglycerol O-acyltransferase 1

Cytoplasm

enzyme

DGC14_HUMAN

DGCR14

DiGeorge syndrome critical region gene 14

Nucleus

other

DHX30_HUMAN

DHX30

DEAH (Asp-Glu-Ala-His) box helicase 30

Nucleus

enzyme

DIP2B_HUMAN

DIP2B

DIP2 disco-interacting protein 2 homolog B (Drosophila)

Cytoplasm

other

DMXL1_HUMAN

DMXL1

Dmx-like 1

Extracellular Space

other

DYH17_HUMAN

DNAH17

dynein, axonemal, heavy chain 17

Cytoplasm

other

DYH2_HUMAN

DNAH2

dynein, axonemal, heavy chain 2

Other

other

DYH3_HUMAN

DNAH3

dynein, axonemal, heavy chain 3

Extracellular Space

enzyme

DYH5_HUMAN

DNAH5

dynein, axonemal, heavy chain 5

Cytoplasm

enzyme

DNJC7_HUMAN

DNAJC7

DnaJ (Hsp40) homolog, subfamily C, member 7

Cytoplasm

other

DOP1_HUMAN

DOPEY1

dopey family member 1

Cytoplasm

other

DSCAM_HUMAN

DSCAM

Down syndrome cell adhesion molecule

Plasma Membrane

other

DUS3L_HUMAN

DUS3L

dihydrouridine synthase 3-like (S. cerevisiae)

Other

other

DYHC2_HUMAN

DYNC2H1

dynein, cytoplasmic 2, heavy chain 1

Cytoplasm

other

COE2_HUMAN

EBF2

early B-cell factor 2

Nucleus

other

EBP_HUMAN

EBP

emopamil binding protein (sterol isomerase)

Cytoplasm

enzyme

EIF3C_HUMAN

EIF3C

eukaryotic translation initiation factor 3, subunit C

Other

translation regulator

ENPP1_HUMAN

ENPP1

ectonucleotide pyrophosphatase/phosphodiesterase 1

Plasma Membrane

enzyme

ENPP5_HUMAN

ENPP5

ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)

Extracellular Space

enzyme

PERE_HUMAN

EPX

eosinophil peroxidase

Cytoplasm

enzyme

EXOS1_HUMAN

EXOSC1

exosome component 1

Nucleus

enzyme

F150A_HUMAN

FAM150A

family with sequence similarity 150, member A

Other

other

F196B_HUMAN

FAM196B

family with sequence similarity 196, member B

Other

other

F208B_HUMAN

FAM208B

family with sequence similarity 208, member B

Other

other

YV021_HUMAN

FAM230B

family with sequence similarity 230, member B (non-protein coding)

Extracellular Space

other

FA78B_HUMAN

FAM78B

family with sequence similarity 78, member B

Other

other

FBF1_HUMAN

FBF1

Fas (TNFRSF6) binding factor 1

Nucleus

other

FIBA_HUMAN

FGA

fibrinogen alpha chain

Extracellular Space

other

FIBB_HUMAN

FGB

fibrinogen beta chain

Extracellular Space

other

FR1OP_HUMAN

FGFR1OP

FGFR1 oncogene partner

Cytoplasm

kinase

FGRL1_HUMAN

FGFRL1

fibroblast growth factor receptor-like 1

Plasma Membrane

transmembrane receptor

FIBG_HUMAN

FGG

fibrinogen gamma chain

Extracellular Space

other

FHAD1_HUMAN

FHAD1

forkhead-associated (FHA) phosphopeptide binding domain 1

Other

other

FIGL2_HUMAN

FIGNL2

fidgetin-like 2

Other

other

FLNB_HUMAN

FLNB

filamin B, beta

Cytoplasm

other

FINC_HUMAN

FN1

fibronectin 1

Extracellular Space

enzyme

FRMD3_HUMAN

FRMD3

FERM domain containing 3

Other

other

G6PC2_HUMAN

G6PC2

glucose-6-phosphatase, catalytic, 2

Cytoplasm

phosphatase

GAK_HUMAN

GAK

cyclin G associated kinase

Nucleus

kinase

GSH0_HUMAN

GCLM

glutamate-cysteine ligase, modifier subunit

Cytoplasm

enzyme

GCN1L_HUMAN

GCN1L1

GCN1 general control of amino-acid synthesis 1-like 1 (yeast)

Cytoplasm

translation regulator

CXB1_HUMAN

GJB1

gap junction protein, beta 1, 32 kDa

Plasma Membrane

transporter

GLRA2_HUMAN

GLRA2

glycine receptor, alpha 2

Plasma Membrane

ion channel

GMEB1_HUMAN

GMEB1

glucocorticoid modulatory element binding protein 1

Nucleus

transcription regulator

GOGA3_HUMAN

GOLGA3

golgin A3

Cytoplasm

transporter

AATC_HUMAN

GOT1

glutamic-oxaloacetic transaminase 1, soluble

Cytoplasm

enzyme

GRID2_HUMAN

GRID2

glutamate receptor, ionotropic, delta 2

Plasma Membrane

ion channel

GSAP_HUMAN

GSAP

gamma-secretase activating protein

Cytoplasm

peptidase

GSAS1_HUMAN

GSN-AS1

GSN antisense RNA 1

Other

other

GSHB_HUMAN

GSS

glutathione synthetase

Cytoplasm

enzyme

HERC1_HUMAN

HERC1

HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

Cytoplasm

other

HES1_HUMAN

HES1

hes family bHLH transcription factor 1

Nucleus

transcription regulator

HILS1_HUMAN

HILS1

histone linker H1 domain, spermatid-specific 1, pseudogene

Nucleus

other

HIP1_HUMAN

HIP1

huntingtin interacting protein 1

Cytoplasm

other

HJURP_HUMAN

HJURP

Holliday junction recognition protein

Nucleus

other

HPTR_HUMAN

HPR

haptoglobin-related protein

Extracellular Space

peptidase

5HT2A_HUMAN

HTR2A

5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled

Plasma Membrane

G-protein coupled receptor

I23O2_HUMAN

IDO2

indoleamine 2,3-dioxygenase 2

Cytoplasm

enzyme

GILT_HUMAN

IFI30

interferon, gamma-inducible protein 30

Cytoplasm

enzyme

IGHA1_HUMAN

IGHA1

immunoglobulin heavy constant alpha 1

Extracellular Space

other

IGHG1_HUMAN

IGHG1

immunoglobulin heavy constant gamma 1 (G1m marker)

Extracellular Space

other

IGHM_HUMAN

IGHM

immunoglobulin heavy constant mu

Plasma Membrane

transmembrane receptor

IGJ_HUMAN

IGJ

immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides

Extracellular Space

other

IGKC_HUMAN

IGKC

immunoglobulin kappa constant

Extracellular Space

other

KV401_HUMAN

IGKV4-1

immunoglobulin kappa variable 4-1

Extracellular Space

other

LAC1_HUMAN

IGLC1

immunoglobulin lambda constant 1 (Mcg marker)

Cytoplasm

other

LAC2_HUMAN

IGLC2

immunoglobulin lambda constant 2 (Kern-Oz- marker)

Extracellular Space

other

IHH_HUMAN

IHH

indian hedgehog

Extracellular Space

enzyme

RED_HUMAN

IK

IK cytokine, down-regulator of HLA II

Extracellular Space

cytokine

IL1AP_HUMAN

IL1RAP

interleukin 1 receptor accessory protein

Plasma Membrane

transmembrane receptor

IRPL2_HUMAN

IL1RAPL2

interleukin 1 receptor accessory protein-like 2

Plasma Membrane

transmembrane receptor

IL26_HUMAN

IL26

interleukin 26

Extracellular Space

cytokine

INCE_HUMAN

INCENP

inner centromere protein antigens 135/155 kDa

Nucleus

other

IQCF6_HUMAN

IQCF6

IQ motif containing F6

Other

other

JARD2_HUMAN

JARID2

jumonji, AT rich interactive domain 2

Nucleus

transcription regulator

KTNB1_HUMAN

KATNB1

katanin p80 (WD repeat containing) subunit B 1

Cytoplasm

enzyme

KCND2_HUMAN

KCND2

potassium voltage-gated channel, Shal-related subfamily, member 2

Plasma Membrane

ion channel

KCNQ5_HUMAN

KCNQ5

potassium voltage-gated channel, KQT-like subfamily, member 5

Plasma Membrane

ion channel

KDM2B_HUMAN

KDM2B

lysine (K)-specific demethylase 2B

Nucleus

other

KDM5A_HUMAN

KDM5A

lysine (K)-specific demethylase 5A

Nucleus

transcription regulator

TALD3_HUMAN

KIAA0586

KIAA0586

Cytoplasm

other

K1161_HUMAN

KIAA1161

KIAA1161

Nucleus

other

KI13A_HUMAN

KIF13A

kinesin family member 13A

Cytoplasm

transporter

KIF19_HUMAN

KIF19

kinesin family member 19

Extracellular Space

enzyme

KIRR1_HUMAN

KIRREL

kin of IRRE like (Drosophila)

Plasma Membrane

other

KLC2_HUMAN

KLC2

kinesin light chain 2

Cytoplasm

other

KLRF1_HUMAN

KLRF1

killer cell lectin-like receptor subfamily F, member 1

Plasma Membrane

transmembrane receptor

LDB1_HUMAN

LDB1

LIM domain binding 1

Nucleus

transcription regulator

LHPL3_HUMAN

LHFPL3

lipoma HMGIC fusion partner-like 3

Other

other

LIPC_HUMAN

LIPC

lipase, hepatic

Extracellular Space

enzyme

YP023_HUMAN

LOC100128265

uncharacterized LOC100128265

Other

other

LRP1B_HUMAN

LRP1B

low density lipoprotein receptor-related protein 1B

Plasma Membrane

transmembrane receptor

LTBP2_HUMAN

LTBP2

latent transforming growth factor beta binding protein 2

Extracellular Space

other

LY75_HUMAN

LY75

lymphocyte antigen 75

Plasma Membrane

transmembrane receptor

MACD1_HUMAN

MACROD1

MACRO domain containing 1

Cytoplasm

enzyme

MANF_HUMAN

MANF

mesencephalic astrocyte-derived neurotrophic factor

Extracellular Space

other

MLP3A_HUMAN

MAP1LC3A

microtubule-associated protein 1 light chain 3 alpha

Cytoplasm

other

MAP4_HUMAN

MAP4

microtubule-associated protein 4

Cytoplasm

other

MA7D3_HUMAN

MAP7D3

MAP7 domain containing 3

Cytoplasm

other

MBD5_HUMAN

MBD5

methyl-CpG binding domain protein 5

Nucleus

other

MDN1_HUMAN

MDN1

MDN1, midasin homolog (yeast)

Nucleus

other

MEX3B_HUMAN

MEX3B

mex-3 RNA binding family member B

Other

kinase

MFNG_HUMAN

MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Cytoplasm

enzyme

MKL1_HUMAN

MKL1

megakaryoblastic leukemia (translocation) 1

Nucleus

transcription regulator

MRE11_HUMAN

MRE11A

MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

Nucleus

enzyme

RM32_HUMAN

MRPL32

mitochondrial ribosomal protein L32

Cytoplasm

translation regulator

MYBA_HUMAN

MYBL1

v-myb avian myeloblastosis viral oncogene homolog-like 1

Nucleus

transcription regulator

MYO15_HUMAN

MYO15A

myosin XVA

Cytoplasm

other

MYO3A_HUMAN

MYO3A

myosin IIIA

Cytoplasm

kinase

MYO6_HUMAN

MYO6

myosin VI

Cytoplasm

other

ULA1_HUMAN

NAE1

NEDD8 activating enzyme E1 subunit 1

Cytoplasm

enzyme

NUCL_HUMAN

NCL

nucleolin

Nucleus

other

NCOA2_HUMAN

NCOA2

nuclear receptor coactivator 2

Nucleus

transcription regulator

NEBU_HUMAN

NEB

nebulin

Cytoplasm

other

NEDD4_HUMAN

NEDD4

neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase

Cytoplasm

enzyme

NHS_HUMAN

NHS

Nance-Horan syndrome (congenital cataracts and dental anomalies)

Nucleus

other

NOA1_HUMAN

NOA1

nitric oxide associated 1

Cytoplasm

other

NRX3A_HUMAN

NRXN3

neurexin 3

Other

transporter

NSD1_HUMAN

NSD1

nuclear receptor binding SET domain protein 1

Nucleus

transcription regulator

NSN5C_HUMAN

NSUN5P2

NOP2/Sun domain family, member 5 pseudogene 2

Other

other

NET5_HUMAN

NTN5

netrin 5

Other

other

NUD15_HUMAN

NUDT15

nudix (nucleoside diphosphate linked moiety X)-type motif 15

Cytoplasm

phosphatase

OBSCN_HUMAN

OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Cytoplasm

kinase

OCEL1_HUMAN

OCEL1

occludin/ELL domain containing 1

Other

other

ODFP2_HUMAN

ODF2

outer dense fiber of sperm tails 2

Cytoplasm

other

NOE2_HUMAN

OLFM2

olfactomedin 2

Cytoplasm

other

OPN4_HUMAN

OPN4

opsin 4

Plasma Membrane

G-protein coupled receptor

OR4K1_HUMAN

OR4K1

olfactory receptor, family 4, subfamily K, member 1

Plasma Membrane

G-protein coupled receptor

PALB2_HUMAN

PALB2

partner and localizer of BRCA2

Nucleus

other

PAR3L_HUMAN

PARD3B

par-3 family cell polarity regulator beta

Plasma Membrane

other

PARP4_HUMAN

PARP4

poly (ADP-ribose) polymerase family, member 4

Cytoplasm

enzyme

PCDH8_HUMAN

PCDH8

protocadherin 8

Plasma Membrane

other

PCLO_HUMAN

PCLO

piccolo presynaptic cytomatrix protein

Cytoplasm

transporter

PEAK1_HUMAN

PEAK1

pseudopodium-enriched atypical kinase 1

Plasma Membrane

kinase

PEG10_HUMAN

PEG10

paternally expressed 10

Nucleus

other

PER3_HUMAN

PER3

period circadian clock 3

Nucleus

other

PFD6_HUMAN

PFDN6

prefoldin subunit 6

Cytoplasm

other

PIGS_HUMAN

PIGS

phosphatidylinositol glycan anchor biosynthesis, class S

Cytoplasm

enzyme

P3C2A_HUMAN

PIK3C2A

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha

Cytoplasm

kinase

SOX_HUMAN

PIPOX

pipecolic acid oxidase

Cytoplasm

enzyme

PLCD3_HUMAN

PLCD3

phospholipase C, delta 3

Cytoplasm

enzyme

PLXA4_HUMAN

PLXNA4

plexin A4

Plasma Membrane

transmembrane receptor

PNKD_HUMAN

PNKD

paroxysmal nonkinesigenic dyskinesia

Nucleus

other

PNKP_HUMAN

PNKP

polynucleotide kinase 3'-phosphatase

Nucleus

kinase

DPOLQ_HUMAN

POLQ

polymerase (DNA directed), theta

Nucleus

enzyme

PMGT1_HUMAN

POMGNT1

protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)

Cytoplasm

enzyme

PPIG_HUMAN

PPIG

peptidylprolyl isomerase G (cyclophilin G)

Nucleus

enzyme

PP12C_HUMAN

PPP1R12C

protein phosphatase 1, regulatory subunit 12C

Cytoplasm

phosphatase

PPT2_HUMAN

PPT2

palmitoyl-protein thioesterase 2

Cytoplasm

enzyme

PREB_HUMAN

PREB

prolactin regulatory element binding

Nucleus

transcription regulator

PPCEL_HUMAN

PREPL

prolyl endopeptidase-like

Other

peptidase

PRG4_HUMAN

PRG4

proteoglycan 4

Extracellular Space

other

PRP31_HUMAN

PRPF31

pre-mRNA processing factor 31

Nucleus

other

PRC2A_HUMAN

PRRC2A

proline-rich coiled-coil 2A

Cytoplasm

other

PSB3_HUMAN

PSMB3

proteasome (prosome, macropain) subunit, beta type, 3

Cytoplasm

peptidase

PRS7_HUMAN

PSMC2

proteasome (prosome, macropain) 26S subunit, ATPase, 2

Nucleus

peptidase

PTPRM_HUMAN

PTPRM

protein tyrosine phosphatase, receptor type, M

Plasma Membrane

phosphatase

PTTG3_HUMAN

PTTG3P

pituitary tumor-transforming 3, pseudogene

Other

other

PZP_HUMAN

PZP

pregnancy-zone protein

Extracellular Space

other

RAB10_HUMAN

RAB10

RAB10, member RAS oncogene family

Cytoplasm

enzyme

RB3GP_HUMAN

RAB3GAP1

RAB3 GTPase activating protein subunit 1 (catalytic)

Cytoplasm

other

RAB6A_HUMAN

RAB6A

RAB6A, member RAS oncogene family

Cytoplasm

enzyme

RAB8B_HUMAN

RAB8B

RAB8B, member RAS oncogene family

Cytoplasm

enzyme

RGPA2_HUMAN

RALGAPA2

Ral GTPase activating protein, alpha subunit 2 (catalytic)

Cytoplasm

other

RBM23_HUMAN

RBM23

RNA binding motif protein 23

Nucleus

other

REG1A_HUMAN

REG1A

regenerating islet-derived 1 alpha

Extracellular Space

growth factor

RELN_HUMAN

RELN

reelin

Extracellular Space

peptidase

RFC4_HUMAN

RFC4

replication factor C (activator 1) 4, 37 kDa

Nucleus

other

RFX8_HUMAN

RFX8

RFX family member 8, lacking RFX DNA binding domain

Other

other

RMND1_HUMAN

RMND1

required for meiotic nuclear division 1 homolog (S. cerevisiae)

Cytoplasm

other

RNF17_HUMAN

RNF17

ring finger protein 17

Cytoplasm

other

RN213_HUMAN

RNF213

ring finger protein 213

Cytoplasm

enzyme

RN219_HUMAN

RNF219

ring finger protein 219

Other

other

FTM_HUMAN

RPGRIP1L

RPGRIP1-like

Cytoplasm

other

RL29_HUMAN

RPL29

ribosomal protein L29

Cytoplasm

other

RL37_HUMAN

RPL37

ribosomal protein L37

Cytoplasm

other

KS6A4_HUMAN

RPS6KA4

ribosomal protein S6 kinase, 90 kDa, polypeptide 4

Cytoplasm

kinase

RTKN_HUMAN

RTKN

rhotekin

Cytoplasm

other

RYR2_HUMAN

RYR2

ryanodine receptor 2 (cardiac)

Plasma Membrane

ion channel

SAMD8_HUMAN

SAMD8

sterile alpha motif domain containing 8

Cytoplasm

other

SASH1_HUMAN

SASH1

SAM and SH3 domain containing 1

Extracellular Space

other

UTER_HUMAN

SCGB1A1

secretoglobin, family 1A, member 1 (uteroglobin)

Extracellular Space

cytokine

SCUB3_HUMAN

SCUBE3

signal peptide, CUB domain, EGF-like 3

Plasma Membrane

other

SPB9_HUMAN

SERPINB9

serpin peptidase inhibitor, clade B (ovalbumin), member 9

Cytoplasm

other

SET1A_HUMAN

SETD1A

SET domain containing 1A

Nucleus

ion channel

SHAN1_HUMAN

SHANK1

SH3 and multiple ankyrin repeat domains 1

Cytoplasm

other

SHAN3_HUMAN

SHANK3

SH3 and multiple ankyrin repeat domains 3

Plasma Membrane

other

CTL1_HUMAN

SLC44A1

solute carrier family 44 (choline transporter), member 1

Plasma Membrane

transporter

SNTAN_HUMAN

SNTN

sentan, cilia apical structure protein

Other

other

SOLH1_HUMAN

SOHLH1

spermatogenesis and oogenesis specific basic helix-loop-helix 1

Cytoplasm

transcription regulator

SPAG7_HUMAN

SPAG7

sperm associated antigen 7

Nucleus

other

SPA2L_HUMAN

SPATA2L

spermatogenesis associated 2-like

Other

other

CYTSB_HUMAN

SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

Nucleus

other

SPO11_HUMAN

SPO11

SPO11 meiotic protein covalently bound to DSB

Nucleus

enzyme

SPTN5_HUMAN

SPTBN5

spectrin, beta, non-erythrocytic 5

Plasma Membrane

other

SRGP2_HUMAN

SRGAP2

SLIT-ROBO Rho GTPase activating protein 2

Cytoplasm

other

SRG2C_HUMAN

SRGAP2C

SLIT-ROBO Rho GTPase activating protein 2C

Other

other

SIA7B_HUMAN

ST6GALNAC2

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

Cytoplasm

enzyme

STXB1_HUMAN

STXBP1

syntaxin binding protein 1

Cytoplasm

transporter

SP20H_HUMAN

SUPT20H

suppressor of Ty 20 homolog (S. cerevisiae)

Nucleus

other

SPT6H_HUMAN

SUPT6H

suppressor of Ty 6 homolog (S. cerevisiae)

Nucleus

transcription regulator

SVEP1_HUMAN

SVEP1

sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

Cytoplasm

other

SYNJ1_HUMAN

SYNJ1

synaptojanin 1

Cytoplasm

phosphatase

TADA3_HUMAN

TADA3

transcriptional adaptor 3

Nucleus

transcription regulator

TBX20_HUMAN

TBX20

T-box 20

Nucleus

transcription regulator

TDRD1_HUMAN

TDRD1

tudor domain containing 1

Cytoplasm

other

TET1_HUMAN

TET1

tet methylcytosine dioxygenase 1

Nucleus

other

THMS1_HUMAN

THEMIS

thymocyte selection associated

Cytoplasm

other

TLK2_HUMAN

TLK2

tousled-like kinase 2

Cytoplasm

kinase

TM131_HUMAN

TMEM131

transmembrane protein 131

Extracellular Space

other

T132C_HUMAN

TMEM132C

transmembrane protein 132C

Other

other

T151A_HUMAN

TMEM151A

transmembrane protein 151A

Other

other

TM232_HUMAN

TMEM232

transmembrane protein 232

Other

other

TNFA_HUMAN

TNF

tumor necrosis factor

Extracellular Space

cytokine

TPD54_HUMAN

TPD52L2

tumor protein D52-like 2

Cytoplasm

other

TRML4_HUMAN

TREML4

triggering receptor expressed on myeloid cells-like 4

Other

other

TRI32_HUMAN

TRIM32

tripartite motif containing 32

Nucleus

transcription regulator

TRI65_HUMAN

TRIM65

tripartite motif containing 65

Other

other

TARA_HUMAN

TRIOBP

TRIO and F-actin binding protein

Nucleus

other

TRIPB_HUMAN

TRIP11

thyroid hormone receptor interactor 11

Cytoplasm

transcription regulator

TROAP_HUMAN

TROAP

trophinin associated protein

Cytoplasm

peptidase

TRPC5_HUMAN

TRPC5

transient receptor potential cation channel, subfamily C, member 5

Plasma Membrane

ion channel

TSG13_HUMAN

TSGA13

testis specific, 13

Other

other

TTC12_HUMAN

TTC12

tetratricopeptide repeat domain 12

Other

other

TITIN_HUMAN

TTN

titin

Cytoplasm

kinase

GCP6_HUMAN

TUBGCP6

tubulin, gamma complex associated protein 6

Cytoplasm

other

TRXR3_HUMAN

TXNRD3

thioredoxin reductase 3

Cytoplasm

enzyme

UBQLN_HUMAN

UBQLNL

ubiquilin-like

Other

other

UCKL1_HUMAN

UCKL1

uridine-cytidine kinase 1-like 1

Cytoplasm

kinase

UGDH_HUMAN

UGDH

UDP-glucose 6-dehydrogenase

Nucleus

enzyme

USP9X_HUMAN

USP9X

ubiquitin specific peptidase 9, X-linked

Plasma Membrane

peptidase

UTRO_HUMAN

UTRN

utrophin

Plasma Membrane

transmembrane receptor

VP13C_HUMAN

VPS13C

vacuolar protein sorting 13 homolog C (S. cerevisiae)

Cytoplasm

other

WAC_HUMAN

WAC

WW domain containing adaptor with coiled-coil

Nucleus

other

WDR1_HUMAN

WDR1

WD repeat domain 1

Extracellular Space

other

WDR35_HUMAN

WDR35

WD repeat domain 35

Cytoplasm

other

WDR43_HUMAN

WDR43

WD repeat domain 43

Nucleus

other

WFDC3_HUMAN

WFDC3

WAP four-disulfide core domain 3

Extracellular Space

other

YIPF1_HUMAN

YIPF1

Yip1 domain family, member 1

Cytoplasm

other

NIPA_HUMAN

ZC3HC1

zinc finger, C3HC-type containing 1

Nucleus

other

ZFHX4_HUMAN

ZFHX4

zinc finger homeobox 4

Extracellular Space

other

ZF64B_HUMAN

ZFP64

ZFP64 zinc finger protein

Nucleus

other

ZN132_HUMAN

ZNF132

zinc finger protein 132

Nucleus

other

ZNF14_HUMAN

ZNF14

zinc finger protein 14

Nucleus

transcription regulator

ZN215_HUMAN

ZNF215

zinc finger protein 215

Nucleus

transcription regulator

Z286B_HUMAN

ZNF286B

zinc finger protein 286B

Other

other

ZN345_HUMAN

ZNF345

zinc finger protein 345

Nucleus

transcription regulator

ZN532_HUMAN

ZNF532

zinc finger protein 532

Other

other

ZN561_HUMAN

ZNF561

zinc finger protein 561

Nucleus

other

ZN624_HUMAN

ZNF624

zinc finger protein 624

Nucleus

other

ZNF74_HUMAN

ZNF74

zinc finger protein 74

Nucleus

other

  1. List of common exosomal proteins are presented as Protein ID, Symbol, Entrez Gene Name, Location and type. No significant differences were observed en exosomal protein content from fresh or frozen plasma (coefficient of variation < 5%) after different freeze thawing cycle from the same sample.