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Table 1 Common proteins identified in exosomes isolated from fresh plasma and after freeze/thawing cycles

From: Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy

Protein ID Symbol Entrez gene name Location Type(s)
A2MG_HUMAN A2M alpha-2-macroglobulin Extracellular Space transporter
A2ML1_HUMAN A2ML1 alpha-2-macroglobulin-like 1 Cytoplasm other
ACACA_HUMAN ACACA acetyl-CoA carboxylase alpha Cytoplasm enzyme
ACTN3_HUMAN ACTN3 actinin, alpha 3 Plasma Membrane other
ADAL_HUMAN ADAL adenosine deaminase-like Cytoplasm enzyme
ATS16_HUMAN ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 Extracellular Space other
ATS9_HUMAN ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 Extracellular Space peptidase
DSRAD_HUMAN ADAR adenosine deaminase, RNA-specific Nucleus enzyme
ADCY7_HUMAN ADCY7 adenylate cyclase 7 Plasma Membrane enzyme
KFA_HUMAN AFMID arylformamidase Nucleus enzyme
ANGT_HUMAN AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Extracellular Space growth factor
ALBU_HUMAN ALB albumin Extracellular Space transporter
AMZ1_HUMAN AMZ1 archaelysin family metallopeptidase 1 Other peptidase
ANK2_HUMAN ANK2 ankyrin 2, neuronal Plasma Membrane other
ANKAR_HUMAN ANKAR ankyrin and armadillo repeat containing Nucleus transcription regulator
AKD1B_HUMAN ANKDD1B ankyrin repeat and death domain containing 1B Other other
ANKL1_HUMAN ANKLE1 ankyrin repeat and LEM domain containing 1 Other other
ANR12_HUMAN ANKRD12 ankyrin repeat domain 12 Nucleus other
ANR26_HUMAN ANKRD26 ankyrin repeat domain 26 Nucleus transcription regulator
ANKUB_HUMAN ANKUB1 ankyrin repeat and ubiquitin domain containing 1 Other other
APOA1_HUMAN APOA1 apolipoprotein A-I Extracellular Space transporter
APOB_HUMAN APOB apolipoprotein B Extracellular Space transporter
APOL1_HUMAN APOL1 apolipoprotein L, 1 Extracellular Space transporter
APOP1_HUMAN APOPT1 apoptogenic 1, mitochondrial Cytoplasm other
DP13B_HUMAN APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 Cytoplasm other
RHG15_HUMAN ARHGAP15 Rho GTPase activating protein 15 Cytoplasm other
RHG08_HUMAN ARHGAP8/PRR5-ARHGAP8 Rho GTPase activating protein 8 Cytoplasm other
ARHGB_HUMAN ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 Cytoplasm other
ASPM_HUMAN ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) Nucleus other
ATG2B_HUMAN ATG2B autophagy related 2B Other other
AT2A3_HUMAN ATP2A3 ATPase, Ca++ transporting, ubiquitous Cytoplasm transporter
RENR_HUMAN ATP6AP2 ATPase, H + transporting, lysosomal accessory protein 2 Cytoplasm transporter
ATR_HUMAN ATR ataxia telangiectasia and Rad3 related Nucleus kinase
B4GT7_HUMAN B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 Cytoplasm enzyme
BEND4_HUMAN BEND4 BEN domain containing 4 Other other
OSTCN_HUMAN BGLAP bone gamma-carboxyglutamate (gla) protein Extracellular Space other
BLM_HUMAN BLM Bloom syndrome, RecQ helicase-like Nucleus enzyme
BRCA2_HUMAN BRCA2 breast cancer 2, early onset Nucleus transcription regulator
BRPF1_HUMAN BRPF1 bromodomain and PHD finger containing, 1 Nucleus transporter
CS068_HUMAN C19orf68 chromosome 19 open reading frame 68 Other other
CA174_HUMAN C1orf174 chromosome 1 open reading frame 174 Nucleus other
CA228_HUMAN C1orf228 chromosome 1 open reading frame 228 Other other
C1QC_HUMAN C1QC complement component 1, q subcomponent, C chain Extracellular Space other
CO3_HUMAN C3 complement component 3 Extracellular Space peptidase
CO4A_HUMAN C4A/C4B complement component 4B (Chido blood group) Extracellular Space other
C4BPA_HUMAN C4BPA complement component 4 binding protein, alpha Extracellular Space other
CI078_HUMAN C9orf78 chromosome 9 open reading frame 78 Other other
CAH3_HUMAN CA3 carbonic anhydrase III, muscle specific Cytoplasm enzyme
CABIN_HUMAN CABIN1 calcineurin binding protein 1 Nucleus other
CAND1_HUMAN CAND1 cullin-associated and neddylation-dissociated 1 Cytoplasm transcription regulator
CAN1_HUMAN CAPN1 calpain 1, (mu/I) large subunit Cytoplasm peptidase
CAN2_HUMAN CAPN2 calpain 2, (m/II) large subunit Cytoplasm peptidase
CASC5_HUMAN CASC5 cancer susceptibility candidate 5 Nucleus other
C8AP2_HUMAN CASP8AP2 caspase 8 associated protein 2 Nucleus transcription regulator
CC154_HUMAN CCDC154 coiled-coil domain containing 154 Other other
CC171_HUMAN CCDC171 coiled-coil domain containing 171 Other other
CCD30_HUMAN CCDC30 coiled-coil domain containing 30 Other other
CCD37_HUMAN CCDC37 coiled-coil domain containing 37 Other other
CCD80_HUMAN CCDC80 coiled-coil domain containing 80 Nucleus other
CCHCR_HUMAN CCHCR1 coiled-coil alpha-helical rod protein 1 Cytoplasm other
CENPH_HUMAN CENPH centromere protein H Nucleus other
CP135_HUMAN CEP135 centrosomal protein 135 kDa Cytoplasm other
CFAH_HUMAN CFH complement factor H Extracellular Space other
CHD4_HUMAN CHD4 chromodomain helicase DNA binding protein 4 Nucleus enzyme
CHD9_HUMAN CHD9 chromodomain helicase DNA binding protein 9 Cytoplasm other
ACHG_HUMAN CHRNG cholinergic receptor, nicotinic, gamma (muscle) Plasma Membrane transmembrane receptor
CHSTB_HUMAN CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 Cytoplasm enzyme
CHSS3_HUMAN CHSY3 chondroitin sulfate synthase 3 Cytoplasm enzyme
CILP1_HUMAN CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase Extracellular Space phosphatase
CLNK_HUMAN CLNK cytokine-dependent hematopoietic cell linker Cytoplasm other
CLUS_HUMAN CLU clusterin Cytoplasm other
CMBL_HUMAN CMBL carboxymethylenebutenolidase homolog (Pseudomonas) Cytoplasm enzyme
CNO6L_HUMAN CNOT6L CCR4-NOT transcription complex, subunit 6-like Cytoplasm enzyme
COPA1_HUMAN COL25A1 collagen, type XXV, alpha 1 Cytoplasm other
CROCC_HUMAN CROCC ciliary rootlet coiled-coil, rootletin Plasma Membrane other
CSRN1_HUMAN CSRNP1 cysteine-serine-rich nuclear protein 1 Nucleus transcription regulator
DIAC_HUMAN CTBS chitobiase, di-N-acetyl- Cytoplasm enzyme
CUL9_HUMAN CUL9 cullin 9 Cytoplasm other
CWC25_HUMAN CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) Other other
CP1A2_HUMAN CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 Cytoplasm enzyme
CP51A_HUMAN CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 Cytoplasm enzyme
DAPL1_HUMAN DAPL1 death associated protein-like 1 Other other
DCAF6_HUMAN DCAF6 DDB1 and CUL4 associated factor 6 Nucleus transcription regulator
DCR1B_HUMAN DCLRE1B DNA cross-link repair 1B Nucleus enzyme
DCSTP_HUMAN DCSTAMP dendrocyte expressed seven transmembrane protein Plasma Membrane other
DCX_HUMAN DCX doublecortin Cytoplasm other
DDX51_HUMAN DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 Other enzyme
DEN2D_HUMAN DENND2D DENN/MADD domain containing 2D Cytoplasm other
DESM_HUMAN DES desmin Cytoplasm other
DGAT1_HUMAN DGAT1 diacylglycerol O-acyltransferase 1 Cytoplasm enzyme
DGC14_HUMAN DGCR14 DiGeorge syndrome critical region gene 14 Nucleus other
DHX30_HUMAN DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 Nucleus enzyme
DIP2B_HUMAN DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) Cytoplasm other
DMXL1_HUMAN DMXL1 Dmx-like 1 Extracellular Space other
DYH17_HUMAN DNAH17 dynein, axonemal, heavy chain 17 Cytoplasm other
DYH2_HUMAN DNAH2 dynein, axonemal, heavy chain 2 Other other
DYH3_HUMAN DNAH3 dynein, axonemal, heavy chain 3 Extracellular Space enzyme
DYH5_HUMAN DNAH5 dynein, axonemal, heavy chain 5 Cytoplasm enzyme
DNJC7_HUMAN DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 Cytoplasm other
DOP1_HUMAN DOPEY1 dopey family member 1 Cytoplasm other
DSCAM_HUMAN DSCAM Down syndrome cell adhesion molecule Plasma Membrane other
DUS3L_HUMAN DUS3L dihydrouridine synthase 3-like (S. cerevisiae) Other other
DYHC2_HUMAN DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 Cytoplasm other
COE2_HUMAN EBF2 early B-cell factor 2 Nucleus other
EBP_HUMAN EBP emopamil binding protein (sterol isomerase) Cytoplasm enzyme
EIF3C_HUMAN EIF3C eukaryotic translation initiation factor 3, subunit C Other translation regulator
ENPP1_HUMAN ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 Plasma Membrane enzyme
ENPP5_HUMAN ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) Extracellular Space enzyme
PERE_HUMAN EPX eosinophil peroxidase Cytoplasm enzyme
EXOS1_HUMAN EXOSC1 exosome component 1 Nucleus enzyme
F150A_HUMAN FAM150A family with sequence similarity 150, member A Other other
F196B_HUMAN FAM196B family with sequence similarity 196, member B Other other
F208B_HUMAN FAM208B family with sequence similarity 208, member B Other other
YV021_HUMAN FAM230B family with sequence similarity 230, member B (non-protein coding) Extracellular Space other
FA78B_HUMAN FAM78B family with sequence similarity 78, member B Other other
FBF1_HUMAN FBF1 Fas (TNFRSF6) binding factor 1 Nucleus other
FIBA_HUMAN FGA fibrinogen alpha chain Extracellular Space other
FIBB_HUMAN FGB fibrinogen beta chain Extracellular Space other
FR1OP_HUMAN FGFR1OP FGFR1 oncogene partner Cytoplasm kinase
FGRL1_HUMAN FGFRL1 fibroblast growth factor receptor-like 1 Plasma Membrane transmembrane receptor
FIBG_HUMAN FGG fibrinogen gamma chain Extracellular Space other
FHAD1_HUMAN FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 Other other
FIGL2_HUMAN FIGNL2 fidgetin-like 2 Other other
FLNB_HUMAN FLNB filamin B, beta Cytoplasm other
FINC_HUMAN FN1 fibronectin 1 Extracellular Space enzyme
FRMD3_HUMAN FRMD3 FERM domain containing 3 Other other
G6PC2_HUMAN G6PC2 glucose-6-phosphatase, catalytic, 2 Cytoplasm phosphatase
GAK_HUMAN GAK cyclin G associated kinase Nucleus kinase
GSH0_HUMAN GCLM glutamate-cysteine ligase, modifier subunit Cytoplasm enzyme
GCN1L_HUMAN GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) Cytoplasm translation regulator
CXB1_HUMAN GJB1 gap junction protein, beta 1, 32 kDa Plasma Membrane transporter
GLRA2_HUMAN GLRA2 glycine receptor, alpha 2 Plasma Membrane ion channel
GMEB1_HUMAN GMEB1 glucocorticoid modulatory element binding protein 1 Nucleus transcription regulator
GOGA3_HUMAN GOLGA3 golgin A3 Cytoplasm transporter
AATC_HUMAN GOT1 glutamic-oxaloacetic transaminase 1, soluble Cytoplasm enzyme
GRID2_HUMAN GRID2 glutamate receptor, ionotropic, delta 2 Plasma Membrane ion channel
GSAP_HUMAN GSAP gamma-secretase activating protein Cytoplasm peptidase
GSAS1_HUMAN GSN-AS1 GSN antisense RNA 1 Other other
GSHB_HUMAN GSS glutathione synthetase Cytoplasm enzyme
HERC1_HUMAN HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Cytoplasm other
HES1_HUMAN HES1 hes family bHLH transcription factor 1 Nucleus transcription regulator
HILS1_HUMAN HILS1 histone linker H1 domain, spermatid-specific 1, pseudogene Nucleus other
HIP1_HUMAN HIP1 huntingtin interacting protein 1 Cytoplasm other
HJURP_HUMAN HJURP Holliday junction recognition protein Nucleus other
HPTR_HUMAN HPR haptoglobin-related protein Extracellular Space peptidase
5HT2A_HUMAN HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Plasma Membrane G-protein coupled receptor
I23O2_HUMAN IDO2 indoleamine 2,3-dioxygenase 2 Cytoplasm enzyme
GILT_HUMAN IFI30 interferon, gamma-inducible protein 30 Cytoplasm enzyme
IGHA1_HUMAN IGHA1 immunoglobulin heavy constant alpha 1 Extracellular Space other
IGHG1_HUMAN IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) Extracellular Space other
IGHM_HUMAN IGHM immunoglobulin heavy constant mu Plasma Membrane transmembrane receptor
IGJ_HUMAN IGJ immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides Extracellular Space other
IGKC_HUMAN IGKC immunoglobulin kappa constant Extracellular Space other
KV401_HUMAN IGKV4-1 immunoglobulin kappa variable 4-1 Extracellular Space other
LAC1_HUMAN IGLC1 immunoglobulin lambda constant 1 (Mcg marker) Cytoplasm other
LAC2_HUMAN IGLC2 immunoglobulin lambda constant 2 (Kern-Oz- marker) Extracellular Space other
IHH_HUMAN IHH indian hedgehog Extracellular Space enzyme
RED_HUMAN IK IK cytokine, down-regulator of HLA II Extracellular Space cytokine
IL1AP_HUMAN IL1RAP interleukin 1 receptor accessory protein Plasma Membrane transmembrane receptor
IRPL2_HUMAN IL1RAPL2 interleukin 1 receptor accessory protein-like 2 Plasma Membrane transmembrane receptor
IL26_HUMAN IL26 interleukin 26 Extracellular Space cytokine
INCE_HUMAN INCENP inner centromere protein antigens 135/155 kDa Nucleus other
IQCF6_HUMAN IQCF6 IQ motif containing F6 Other other
JARD2_HUMAN JARID2 jumonji, AT rich interactive domain 2 Nucleus transcription regulator
KTNB1_HUMAN KATNB1 katanin p80 (WD repeat containing) subunit B 1 Cytoplasm enzyme
KCND2_HUMAN KCND2 potassium voltage-gated channel, Shal-related subfamily, member 2 Plasma Membrane ion channel
KCNQ5_HUMAN KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5 Plasma Membrane ion channel
KDM2B_HUMAN KDM2B lysine (K)-specific demethylase 2B Nucleus other
KDM5A_HUMAN KDM5A lysine (K)-specific demethylase 5A Nucleus transcription regulator
TALD3_HUMAN KIAA0586 KIAA0586 Cytoplasm other
K1161_HUMAN KIAA1161 KIAA1161 Nucleus other
KI13A_HUMAN KIF13A kinesin family member 13A Cytoplasm transporter
KIF19_HUMAN KIF19 kinesin family member 19 Extracellular Space enzyme
KIRR1_HUMAN KIRREL kin of IRRE like (Drosophila) Plasma Membrane other
KLC2_HUMAN KLC2 kinesin light chain 2 Cytoplasm other
KLRF1_HUMAN KLRF1 killer cell lectin-like receptor subfamily F, member 1 Plasma Membrane transmembrane receptor
LDB1_HUMAN LDB1 LIM domain binding 1 Nucleus transcription regulator
LHPL3_HUMAN LHFPL3 lipoma HMGIC fusion partner-like 3 Other other
LIPC_HUMAN LIPC lipase, hepatic Extracellular Space enzyme
YP023_HUMAN LOC100128265 uncharacterized LOC100128265 Other other
LRP1B_HUMAN LRP1B low density lipoprotein receptor-related protein 1B Plasma Membrane transmembrane receptor
LTBP2_HUMAN LTBP2 latent transforming growth factor beta binding protein 2 Extracellular Space other
LY75_HUMAN LY75 lymphocyte antigen 75 Plasma Membrane transmembrane receptor
MACD1_HUMAN MACROD1 MACRO domain containing 1 Cytoplasm enzyme
MANF_HUMAN MANF mesencephalic astrocyte-derived neurotrophic factor Extracellular Space other
MLP3A_HUMAN MAP1LC3A microtubule-associated protein 1 light chain 3 alpha Cytoplasm other
MAP4_HUMAN MAP4 microtubule-associated protein 4 Cytoplasm other
MA7D3_HUMAN MAP7D3 MAP7 domain containing 3 Cytoplasm other
MBD5_HUMAN MBD5 methyl-CpG binding domain protein 5 Nucleus other
MDN1_HUMAN MDN1 MDN1, midasin homolog (yeast) Nucleus other
MEX3B_HUMAN MEX3B mex-3 RNA binding family member B Other kinase
MFNG_HUMAN MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Cytoplasm enzyme
MKL1_HUMAN MKL1 megakaryoblastic leukemia (translocation) 1 Nucleus transcription regulator
MRE11_HUMAN MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) Nucleus enzyme
RM32_HUMAN MRPL32 mitochondrial ribosomal protein L32 Cytoplasm translation regulator
MYBA_HUMAN MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 Nucleus transcription regulator
MYO15_HUMAN MYO15A myosin XVA Cytoplasm other
MYO3A_HUMAN MYO3A myosin IIIA Cytoplasm kinase
MYO6_HUMAN MYO6 myosin VI Cytoplasm other
ULA1_HUMAN NAE1 NEDD8 activating enzyme E1 subunit 1 Cytoplasm enzyme
NUCL_HUMAN NCL nucleolin Nucleus other
NCOA2_HUMAN NCOA2 nuclear receptor coactivator 2 Nucleus transcription regulator
NEBU_HUMAN NEB nebulin Cytoplasm other
NEDD4_HUMAN NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase Cytoplasm enzyme
NHS_HUMAN NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) Nucleus other
NOA1_HUMAN NOA1 nitric oxide associated 1 Cytoplasm other
NRX3A_HUMAN NRXN3 neurexin 3 Other transporter
NSD1_HUMAN NSD1 nuclear receptor binding SET domain protein 1 Nucleus transcription regulator
NSN5C_HUMAN NSUN5P2 NOP2/Sun domain family, member 5 pseudogene 2 Other other
NET5_HUMAN NTN5 netrin 5 Other other
NUD15_HUMAN NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 Cytoplasm phosphatase
OBSCN_HUMAN OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Cytoplasm kinase
OCEL1_HUMAN OCEL1 occludin/ELL domain containing 1 Other other
ODFP2_HUMAN ODF2 outer dense fiber of sperm tails 2 Cytoplasm other
NOE2_HUMAN OLFM2 olfactomedin 2 Cytoplasm other
OPN4_HUMAN OPN4 opsin 4 Plasma Membrane G-protein coupled receptor
OR4K1_HUMAN OR4K1 olfactory receptor, family 4, subfamily K, member 1 Plasma Membrane G-protein coupled receptor
PALB2_HUMAN PALB2 partner and localizer of BRCA2 Nucleus other
PAR3L_HUMAN PARD3B par-3 family cell polarity regulator beta Plasma Membrane other
PARP4_HUMAN PARP4 poly (ADP-ribose) polymerase family, member 4 Cytoplasm enzyme
PCDH8_HUMAN PCDH8 protocadherin 8 Plasma Membrane other
PCLO_HUMAN PCLO piccolo presynaptic cytomatrix protein Cytoplasm transporter
PEAK1_HUMAN PEAK1 pseudopodium-enriched atypical kinase 1 Plasma Membrane kinase
PEG10_HUMAN PEG10 paternally expressed 10 Nucleus other
PER3_HUMAN PER3 period circadian clock 3 Nucleus other
PFD6_HUMAN PFDN6 prefoldin subunit 6 Cytoplasm other
PIGS_HUMAN PIGS phosphatidylinositol glycan anchor biosynthesis, class S Cytoplasm enzyme
P3C2A_HUMAN PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha Cytoplasm kinase
SOX_HUMAN PIPOX pipecolic acid oxidase Cytoplasm enzyme
PLCD3_HUMAN PLCD3 phospholipase C, delta 3 Cytoplasm enzyme
PLXA4_HUMAN PLXNA4 plexin A4 Plasma Membrane transmembrane receptor
PNKD_HUMAN PNKD paroxysmal nonkinesigenic dyskinesia Nucleus other
PNKP_HUMAN PNKP polynucleotide kinase 3'-phosphatase Nucleus kinase
DPOLQ_HUMAN POLQ polymerase (DNA directed), theta Nucleus enzyme
PMGT1_HUMAN POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) Cytoplasm enzyme
PPIG_HUMAN PPIG peptidylprolyl isomerase G (cyclophilin G) Nucleus enzyme
PP12C_HUMAN PPP1R12C protein phosphatase 1, regulatory subunit 12C Cytoplasm phosphatase
PPT2_HUMAN PPT2 palmitoyl-protein thioesterase 2 Cytoplasm enzyme
PREB_HUMAN PREB prolactin regulatory element binding Nucleus transcription regulator
PPCEL_HUMAN PREPL prolyl endopeptidase-like Other peptidase
PRG4_HUMAN PRG4 proteoglycan 4 Extracellular Space other
PRP31_HUMAN PRPF31 pre-mRNA processing factor 31 Nucleus other
PRC2A_HUMAN PRRC2A proline-rich coiled-coil 2A Cytoplasm other
PSB3_HUMAN PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 Cytoplasm peptidase
PRS7_HUMAN PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 Nucleus peptidase
PTPRM_HUMAN PTPRM protein tyrosine phosphatase, receptor type, M Plasma Membrane phosphatase
PTTG3_HUMAN PTTG3P pituitary tumor-transforming 3, pseudogene Other other
PZP_HUMAN PZP pregnancy-zone protein Extracellular Space other
RAB10_HUMAN RAB10 RAB10, member RAS oncogene family Cytoplasm enzyme
RB3GP_HUMAN RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) Cytoplasm other
RAB6A_HUMAN RAB6A RAB6A, member RAS oncogene family Cytoplasm enzyme
RAB8B_HUMAN RAB8B RAB8B, member RAS oncogene family Cytoplasm enzyme
RGPA2_HUMAN RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) Cytoplasm other
RBM23_HUMAN RBM23 RNA binding motif protein 23 Nucleus other
REG1A_HUMAN REG1A regenerating islet-derived 1 alpha Extracellular Space growth factor
RELN_HUMAN RELN reelin Extracellular Space peptidase
RFC4_HUMAN RFC4 replication factor C (activator 1) 4, 37 kDa Nucleus other
RFX8_HUMAN RFX8 RFX family member 8, lacking RFX DNA binding domain Other other
RMND1_HUMAN RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) Cytoplasm other
RNF17_HUMAN RNF17 ring finger protein 17 Cytoplasm other
RN213_HUMAN RNF213 ring finger protein 213 Cytoplasm enzyme
RN219_HUMAN RNF219 ring finger protein 219 Other other
FTM_HUMAN RPGRIP1L RPGRIP1-like Cytoplasm other
RL29_HUMAN RPL29 ribosomal protein L29 Cytoplasm other
RL37_HUMAN RPL37 ribosomal protein L37 Cytoplasm other
KS6A4_HUMAN RPS6KA4 ribosomal protein S6 kinase, 90 kDa, polypeptide 4 Cytoplasm kinase
RTKN_HUMAN RTKN rhotekin Cytoplasm other
RYR2_HUMAN RYR2 ryanodine receptor 2 (cardiac) Plasma Membrane ion channel
SAMD8_HUMAN SAMD8 sterile alpha motif domain containing 8 Cytoplasm other
SASH1_HUMAN SASH1 SAM and SH3 domain containing 1 Extracellular Space other
UTER_HUMAN SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) Extracellular Space cytokine
SCUB3_HUMAN SCUBE3 signal peptide, CUB domain, EGF-like 3 Plasma Membrane other
SPB9_HUMAN SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 Cytoplasm other
SET1A_HUMAN SETD1A SET domain containing 1A Nucleus ion channel
SHAN1_HUMAN SHANK1 SH3 and multiple ankyrin repeat domains 1 Cytoplasm other
SHAN3_HUMAN SHANK3 SH3 and multiple ankyrin repeat domains 3 Plasma Membrane other
CTL1_HUMAN SLC44A1 solute carrier family 44 (choline transporter), member 1 Plasma Membrane transporter
SNTAN_HUMAN SNTN sentan, cilia apical structure protein Other other
SOLH1_HUMAN SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 Cytoplasm transcription regulator
SPAG7_HUMAN SPAG7 sperm associated antigen 7 Nucleus other
SPA2L_HUMAN SPATA2L spermatogenesis associated 2-like Other other
CYTSB_HUMAN SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 Nucleus other
SPO11_HUMAN SPO11 SPO11 meiotic protein covalently bound to DSB Nucleus enzyme
SPTN5_HUMAN SPTBN5 spectrin, beta, non-erythrocytic 5 Plasma Membrane other
SRGP2_HUMAN SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 Cytoplasm other
SRG2C_HUMAN SRGAP2C SLIT-ROBO Rho GTPase activating protein 2C Other other
SIA7B_HUMAN ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 Cytoplasm enzyme
STXB1_HUMAN STXBP1 syntaxin binding protein 1 Cytoplasm transporter
SP20H_HUMAN SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) Nucleus other
SPT6H_HUMAN SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) Nucleus transcription regulator
SVEP1_HUMAN SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Cytoplasm other
SYNJ1_HUMAN SYNJ1 synaptojanin 1 Cytoplasm phosphatase
TADA3_HUMAN TADA3 transcriptional adaptor 3 Nucleus transcription regulator
TBX20_HUMAN TBX20 T-box 20 Nucleus transcription regulator
TDRD1_HUMAN TDRD1 tudor domain containing 1 Cytoplasm other
TET1_HUMAN TET1 tet methylcytosine dioxygenase 1 Nucleus other
THMS1_HUMAN THEMIS thymocyte selection associated Cytoplasm other
TLK2_HUMAN TLK2 tousled-like kinase 2 Cytoplasm kinase
TM131_HUMAN TMEM131 transmembrane protein 131 Extracellular Space other
T132C_HUMAN TMEM132C transmembrane protein 132C Other other
T151A_HUMAN TMEM151A transmembrane protein 151A Other other
TM232_HUMAN TMEM232 transmembrane protein 232 Other other
TNFA_HUMAN TNF tumor necrosis factor Extracellular Space cytokine
TPD54_HUMAN TPD52L2 tumor protein D52-like 2 Cytoplasm other
TRML4_HUMAN TREML4 triggering receptor expressed on myeloid cells-like 4 Other other
TRI32_HUMAN TRIM32 tripartite motif containing 32 Nucleus transcription regulator
TRI65_HUMAN TRIM65 tripartite motif containing 65 Other other
TARA_HUMAN TRIOBP TRIO and F-actin binding protein Nucleus other
TRIPB_HUMAN TRIP11 thyroid hormone receptor interactor 11 Cytoplasm transcription regulator
TROAP_HUMAN TROAP trophinin associated protein Cytoplasm peptidase
TRPC5_HUMAN TRPC5 transient receptor potential cation channel, subfamily C, member 5 Plasma Membrane ion channel
TSG13_HUMAN TSGA13 testis specific, 13 Other other
TTC12_HUMAN TTC12 tetratricopeptide repeat domain 12 Other other
TITIN_HUMAN TTN titin Cytoplasm kinase
GCP6_HUMAN TUBGCP6 tubulin, gamma complex associated protein 6 Cytoplasm other
TRXR3_HUMAN TXNRD3 thioredoxin reductase 3 Cytoplasm enzyme
UBQLN_HUMAN UBQLNL ubiquilin-like Other other
UCKL1_HUMAN UCKL1 uridine-cytidine kinase 1-like 1 Cytoplasm kinase
UGDH_HUMAN UGDH UDP-glucose 6-dehydrogenase Nucleus enzyme
USP9X_HUMAN USP9X ubiquitin specific peptidase 9, X-linked Plasma Membrane peptidase
UTRO_HUMAN UTRN utrophin Plasma Membrane transmembrane receptor
VP13C_HUMAN VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) Cytoplasm other
WAC_HUMAN WAC WW domain containing adaptor with coiled-coil Nucleus other
WDR1_HUMAN WDR1 WD repeat domain 1 Extracellular Space other
WDR35_HUMAN WDR35 WD repeat domain 35 Cytoplasm other
WDR43_HUMAN WDR43 WD repeat domain 43 Nucleus other
WFDC3_HUMAN WFDC3 WAP four-disulfide core domain 3 Extracellular Space other
YIPF1_HUMAN YIPF1 Yip1 domain family, member 1 Cytoplasm other
NIPA_HUMAN ZC3HC1 zinc finger, C3HC-type containing 1 Nucleus other
ZFHX4_HUMAN ZFHX4 zinc finger homeobox 4 Extracellular Space other
ZF64B_HUMAN ZFP64 ZFP64 zinc finger protein Nucleus other
ZN132_HUMAN ZNF132 zinc finger protein 132 Nucleus other
ZNF14_HUMAN ZNF14 zinc finger protein 14 Nucleus transcription regulator
ZN215_HUMAN ZNF215 zinc finger protein 215 Nucleus transcription regulator
Z286B_HUMAN ZNF286B zinc finger protein 286B Other other
ZN345_HUMAN ZNF345 zinc finger protein 345 Nucleus transcription regulator
ZN532_HUMAN ZNF532 zinc finger protein 532 Other other
ZN561_HUMAN ZNF561 zinc finger protein 561 Nucleus other
ZN624_HUMAN ZNF624 zinc finger protein 624 Nucleus other
ZNF74_HUMAN ZNF74 zinc finger protein 74 Nucleus other
  1. List of common exosomal proteins are presented as Protein ID, Symbol, Entrez Gene Name, Location and type. No significant differences were observed en exosomal protein content from fresh or frozen plasma (coefficient of variation < 5%) after different freeze thawing cycle from the same sample.
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Journal of Translational Medicine

ISSN: 1479-5876

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