Contribution of placental-derived exosomes into maternal circulation. (A) Relationship between exosomal PLAP and exosomes (particles per ml plasma) across first trimester of pregnancy (i.e. 6–12 weeks represented by colours). (B) Ratio of specific placental exosome and exosomes. In A, values are mean ± SEM, Linear correlation (−). In B, Data are presented as aligned dot plot and values are mean ± SEM, two-way ANOVA p > 0.05.