| |
Bootstrap analysis Median [5-95th percentiles]
|
|---|
|
Parameters
|
Estimates (RSE%)
|
BAV (RSE%)
|
Estimates
|
BAV
|
|---|
|
Clozapine
| | | | |
|
CLclo/F (L/min)
|
0.5(20.3)
| |
0.463[0.358-0.661]
| |
|
Vclo-p/F (L)
|
19.4(40.3)
| |
18.9[5.43-31.59]
| |
|
Kaclo (1/min)
|
0.00801(14.7)
| |
0.00815[0.0051-0.0095]
| |
|
Qclo/F (L/min)
|
2.01(40.8)
|
0.193(33.6)
|
2.08[0.58-3.43]
|
0.2[0.07-0.29]
|
|
Vclo-b/F (L)
|
0.214 FIXED
| | | |
|
Ktr1 (1/min)
|
0.0125(9.4)
|
0.05 (48.9)
|
0.0129[0.011-0.015]
|
0.047[0.0033-0.069]
|
|
Fclo
|
1 FIXED
|
0.259(37.1)
| |
0.243[0.062-0.35]
|
|
Norclozapine
| | | | |
|
Clclo-met/F (L/min)
|
0.055(24.8)
| |
0.0584[0.04-0.0855]
| |
|
CLmet/F (L/min)
|
0.419(18.8)
|
0.111(74.8)
|
0.43[0.33-0.61]
|
0.08[0.0038-0.18]
|
|
Vmet-p/F (L)
|
2.95(38.6)
|
0.168(51.1)
|
3.02[1.91-5.55]
|
0.149[0.000047-0.27]
|
|
Kamet (1/min)
|
0.00277(31)
|
0.371(44.2)
|
0.00296[0.0015-0.0047]
|
0.319[0.065-0.54]
|
|
Qmet/F (L/min)
|
0.388(45)
| |
0.386[0.229-0.768]
| |
|
Vmet-b/F (L)
|
0.25 FIXED
| | | |
|
Ktr2 (1/min)
|
0.00517(12.3)
| |
0.00521[0.0045-0.0064]
| |
|
Fmet
|
1 FIXED
| | | |
|
Residual error (proportional)
| | | | |
|
Parent-plasma
|
0.109(70)
| |
0.084[0.029-0.19]
| |
|
Parent-brain
|
0.0367(27)
| |
0.0371[0.023-0.055]
| |
|
Metabolite-plasma
|
0.0762(24.1)
| |
0.0714[0.051-0.11]
| |
|
Metabolite-brain
|
0.014(18)
| |
0.0133[0.0095-0.017]
| |
- Clo (Clozapine): CLclo/F (L/min) = apparent clearance of clozapine; Vclo-p/F (L) = apparent volume of distribution of clozapine in plasma; Kaclo (1/min) = absorption rate of clozapine; Qclo/F (L/min) = apparent intercompartmental clearance of clozapine;
- Vclo-b/F (L) = apparent volume of distribution of clozapine in brain; Ktr1 (1/min) = transit rate constant of clozapine.
- Met (Norclozapine): CLclo-met/F (L/min) = apparent clearance of clozapine to norclozapine; CLmet/F (L/min) = apparent clearance of norclozapine; Vmet-p/F (L) = apparent volume of distribution of norclozapine in plasma; Kamet (1/min) = absorption rate of norclozapine; Qmet/F (L/min) = apparent intercompartmental clearance of norclozapine; Vmet-b/F (L) = apparent volume of distribution of norclozapine in brain; Ktr2 (1/min) = transit rate constant of norclozapine.
- BAV = between animal variability.
- RSE% = percent relative standard error.
