Figure 7

The predicted median percentage of receptor occupancy of D2, 5-HT2A, M1, α1, α2 and H1 for clozapine and D2 for norclozapine. The predicted median percentage of receptor occupancy of D2, 5-HT2A, M1, α1, α2 and H1 for clozapine were shown in A to F, respectively, and predicted median percentage of receptor occupancy of D2 for norclozapine was shown in G between 6 to 24 hour after dose. The solid line, dash line and dot line represent the predicted median percentage of receptor occupancy following 200, 300 and 400 mg daily doses, respectively.