Figure 5From: Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokinetics Visual predictive checks of norclozapine in plasma and brain. Visual predictive check of norclozapine concentrations in plasma (A) and brain (B) following a 10Â mg/kg subcutaneous dose of norclozapine. Dashed line is the median of observed concentrations, the shape represents the 90% predicted interval of the median, and the dots represent the observed concentrations.Back to article page