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Table 2 Results of univariate and multivariate Cox proportional-hazards analysis in the overall patient for death

From: Aurora-A contributes to cisplatin resistance and lymphatic metastasis in non-small cell lung cancer and predicts poor prognosis

 

For death

Variable

Univariate analysis

Multivariate analysis

 

Hazard ratio

95% confidence interval

P

Hazard ratio

95% confidence interval

P

Age (years) ≥ 60.00 (VS. < 60.0)

1.186

(0.734 to 1.916)

0.487

1.016

(0.603 to 1.712)

0.952

Gender Male (VS. Female)

1.249

(0.752 to 2.074)

0.391

1.057

(0.451 to 2.477)

0.899

Smoking history Yes (VS. No)

1.504

(0.941 to 2.406)

0.088

1.520

(0.930 to 2.458)

0.095

CEA (ng/ml) > 5 (VS. ≤ 5)

2.070

(1.288 to 3.326)

0.003

2.034

(1.223 to 3.385)

0.006

Initial clinical stage

      

I

0.187

(0.058 to 0.601)

0.005

0.281

(0.086 to 0.917)

0.035

II

0.449

(0.248 to 0.812)

0.008

0.724

(0.384 to 1.364)

0.317

III

1

1

 

1

1

 

Histology

      

Squamous cell carcinoma

1.898

(0.263 to 13.700)

0.525

5.540

(0.749 to 40.949)

0.093

Adenocarcinoma

2.191

(0.277 to 17.325)

0.457

5.725

(0.688 to 47.634)

0.107

Adenosquamous cell carcinomas

1

1

 

1

1

 

Differentiatiation

      

Highly

0.581

(0.281 to 1.200)

0.142

1.138

(0.514 to 2.521)

0.750

Moderately

0.796

(0.479 to 1.322)

0.377

0.993

(0.562 to 1.757)

0.982

Poorly

1

1

 

1

1

 

Tumor stage T 4  + T 3 (VS. T 2  + T 1 )

1.534

(0.962 to 2.445)

0.072

1.295

(0.752 to 2.230)

0.352

Lymph node metastasis Positive (VS. Negative)

2.460

(1.319 to 4.588)

0.005

1.484

(0.519 to 4.247)

0.462

Aurora-A High (VS. Low)

2.971

(1.803 to 4.895)

0.000

3.311

(1.899 to 5.775)

0.000