| For death | |||||
---|---|---|---|---|---|---|
Variable | Univariate analysis | Multivariate analysis | ||||
 | Hazard ratio | 95% confidence interval | P | Hazard ratio | 95% confidence interval | P |
Age (years) ≥ 60.00 (VS. < 60.0) | 1.186 | (0.734 to 1.916) | 0.487 | 1.016 | (0.603 to 1.712) | 0.952 |
Gender Male (VS. Female) | 1.249 | (0.752 to 2.074) | 0.391 | 1.057 | (0.451 to 2.477) | 0.899 |
Smoking history Yes (VS. No) | 1.504 | (0.941 to 2.406) | 0.088 | 1.520 | (0.930 to 2.458) | 0.095 |
CEA (ng/ml) > 5 (VS. ≤ 5) | 2.070 | (1.288 to 3.326) | 0.003 | 2.034 | (1.223 to 3.385) | 0.006 |
Initial clinical stage | Â | Â | Â | Â | Â | Â |
I | 0.187 | (0.058 to 0.601) | 0.005 | 0.281 | (0.086 to 0.917) | 0.035 |
II | 0.449 | (0.248 to 0.812) | 0.008 | 0.724 | (0.384 to 1.364) | 0.317 |
III | 1 | 1 | Â | 1 | 1 | Â |
Histology | Â | Â | Â | Â | Â | Â |
Squamous cell carcinoma | 1.898 | (0.263 to 13.700) | 0.525 | 5.540 | (0.749 to 40.949) | 0.093 |
Adenocarcinoma | 2.191 | (0.277 to 17.325) | 0.457 | 5.725 | (0.688 to 47.634) | 0.107 |
Adenosquamous cell carcinomas | 1 | 1 | Â | 1 | 1 | Â |
Differentiatiation | Â | Â | Â | Â | Â | Â |
Highly | 0.581 | (0.281 to 1.200) | 0.142 | 1.138 | (0.514 to 2.521) | 0.750 |
Moderately | 0.796 | (0.479 to 1.322) | 0.377 | 0.993 | (0.562 to 1.757) | 0.982 |
Poorly | 1 | 1 | Â | 1 | 1 | Â |
Tumor stage T 4  + T 3 (VS. T 2  + T 1 ) | 1.534 | (0.962 to 2.445) | 0.072 | 1.295 | (0.752 to 2.230) | 0.352 |
Lymph node metastasis Positive (VS. Negative) | 2.460 | (1.319 to 4.588) | 0.005 | 1.484 | (0.519 to 4.247) | 0.462 |
Aurora-A High (VS. Low) | 2.971 | (1.803 to 4.895) | 0.000 | 3.311 | (1.899 to 5.775) | 0.000 |