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Table 3 Expression of metabolism-related proteins in PUMC according to clinical subtypes

From: Metabolic phenotypes in primary unknown metastatic carcinoma

Immunohistochemical parameters Total (n = 77) (%) Clinical subtype p-value
Nodal type (n = 34) (%) Single organ type (n = 15) (%) Intermediate type (n = 14) (%) Carcinomatosis type (n = 14)(%)
Glut-1 (T)       0.021
 Negative 41 (53.2) 13 (38.2) 9 (60.0) 9 (64.3) 10 (71.4)  
 Positive 36 (46.8) 21 (61.8) 6 (40.0) 5 (35.7) 4 (28.6)  
Glut-1 (S)       N/A
 Negative 77 (100.0) 34 (100.0) 15 (100.0) 14 (100.0) 14 (100.0)  
 Positive 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0)  
CAIX (T)       0.372
 Negative 68 (88.3) 28 (82.4) 15 (100.0) 12 (85.7) 13 (92.9)  
 Positive 9 (11.7) 6 (17.6) 0 (0.0) 2 (14.3) 1 (7.1)  
CAIX (S)       0.458
 Negative 75 (97.4) 33 (97.1) 14 (93.3) 14 (100.0) 14 (100.0)  
 Positive 2 (2.6) 1 (2.9) 1 (6.7) 0 (0.0) 0 (0.0)  
MCT4 (T)       0.877
 Negative 22 (28.6) 11 (32.4) 2 (13.3) 4 (28.6) 5 (35.7)  
 Positive 55 (71.4) 23 (67.6) 13 (86.7) 10 (71.4) 9 (64.3)  
MCT4 (S)       0.372
 Negative 43 (55.8) 17 (50.0) 9 (60.0) 8 (57.1) 9 (64.3)  
 Positive 34 (44.2) 17 (50.0) 6 (40.0) 6 (42.9) 5 (35.7)  
GLS1 (T)       0.176
 Negative 46 (59.7) 23 (67.6) 8 (53.3) 9 (64.3) 6 (42.9)  
 Positive 31 (40.3) 11 (32.4) 7 (46.7) 5 (35.7) 8 (57.1)  
GLS1 (S)       0.123
 Negative 68 (88.3) 31 (91.2) 14 (93.3) 13 (92.9) 10 (71.4)  
 Positive 9 (11.7) 3 (8.8) 1 (6.7) 1 (7.1) 4 (28.6)  
GDH (T)       0.181
 Negative 8 (10.4) 2 (5.9) 2 (13.3) 1 (7.1) 3 (21.4)  
 Positive 69 (89.6) 32 (94.1) 13 (86.7) 13 (92.9) 11 (78.6)  
GDH (S)       0.816
 Negative 58 (75.3) 27 (79.4) 10 (66.7) 10 (71.4) 11 (78.6)  
 Positive 19 (24.7) 7 (20.6) 5 (33.3) 4 (28.6) 3 (21.4)  
ASCT2 (T)       0.823
 Negative 47 (61.0) 19 (55.9) 11 (73.3) 9 (64.3) 8 (57.1)  
 Positive 30 (39.0) 15 (44.1) 4 (26.7) 5 (35.7) 6 (42.9)  
ASCT2 (S)       0.255
 Negative 73 (94.8) 33 (97.1) 15 (100.0) 12 (85.7) 13 (92.9)  
 Positive 4 (5.2) 1 (2.9) 0 (0.0) 2 (14.3) 1 (7.1)  
ATP synthase (T)       0.626
 Negative 2 (2.6) 1 (2.9) 0 (0.0) 0 (0.0) 1 (7.1)  
 Positive 75 (97.4) 33 (97.1) 15 (100.0) 14 (100.0) 13 (92.9)  
ATP synthase (S)       0.395
 Negative 62 (80.5) 29 (85.3) 11 (73.3) 12 (85.7) 10 (71.4)  
 Positive 15 (19.5) 5 (14.7) 4 (26.7) 2 (14.3) 4 (28.6)  
SDHA (T)       0.393
 Negative 3 (3.9) 1 (2.9) 0 (0.0) 1 (7.1) 1 (7.1)  
 Positive 74 (96.1) 33 (97.1) 15 (100.0) 13 (92.9) 13 (92.9)  
SDHA (S)       0.794
 Negative 59 (76.6) 27 (79.4) 11 (73.3) 10 (71.4) 11 (78.6)  
 Positive 18 (23.4) 7 (20.6) 4 (26.7) 4 (28.6) 3 (21.4)  
SDHB (T)       0.230
 Negative 28 (36.4) 16 (47.1) 3 (20.0) 5 (35.7) 4 (28.6)  
 Positive 49 (63.6) 18 (52.9) 12 (80.0) 9 (64.3) 10 (71.4)  
SDHB (S)       0.968
 Negative 66 (85.7) 30 (88.2) 11 (73.3) 13 (92.9) 12 (85.7)  
 Positive 11 (14.3) 4 (11.8) 4 (26.7) 1 (7.1) 2 (14.3)  
  1. Bold represents p<0.05.