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Table 2 Expression of metabolism-related proteins in PUMC according to histologic subtypes

From: Metabolic phenotypes in primary unknown metastatic carcinoma

Immunohistochemical parameters Total N = 77 (%) Histologic subtype p-value
AD (n = 27) (%) PD (n = 16) (%) SQ (n = 20) (%) UD (n = 14) (%)
Glut-1 (T)       0.028
 Negative 41 (53.2) 17 (63.0) 11 (68.8) 5 (25.0) 8 (57.1)  
 Positive 36 (46.8) 10 (37.0) 5 (31.3) 15 (75.0) 6 (42.9)  
Glut-1 (S)       N/A
 Negative 77 (100.0) 27 (100.0) 16 (100.0) 20 (100.0) 14 (100.0)  
 Positive 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0)  
CAIX (T)       0.124
 Negative 68 (88.3) 24 (88.9) 15 (93.8) 15 (75.0) 14 (100.0)  
 Positive 9 (11.7) 3 (11.1) 1 (6.3) 5 (25.0) 0 (0.0)  
CAIX (S)       0.050
 Negative 75 (97.4) 27 (100.0) 14 (87.5) 20 (100.0) 14 (100.0)  
 Positive 2 (2.6) 0 (0.0) 2 (12.5) 0 (0.0) 0 (0.0)  
MCT4 (T)       0.409
 Negative 22 (28.6) 8 (29.6) 7 (43.8) 4 (20.0) 3 (21.4)  
 Positive 55 (71.4) 19 (70.4) 9 (56.3) 16 (80.0) 11 (78.6)  
MCT4 (S)       0.902
 Negative 43 (55.8) 15 (55.6) 10 (62.5) 10 (50.0) 8 (57.1)  
 Positive 34 (44.2) 12 (44.4) 6 (37.5) 10 (50.0) 6 (42.9)  
GLS1 (T)       0.184
 Negative 46 (59.7) 14 (51.9) 11 (68.8) 15 (75.0) 6 (42.9)  
 Positive 31 (40.3) 13 (48.1) 5 (31.3) 5 (25.0) 8 (57.1)  
GLS1 (S)       0.401
 Negative 68 (88.3) 23 (85.2) 13 (81.3) 18 (90.0) 14 (100.0)  
 Positive 9 (11.7) 4 (14.8) 3 (18.8) 2 (10.0) 0 (0.0)  
GDH (T)       0.510
 Negative 8 (10.4) 2 (7.4) 3 (18.8) 1 (5.0) 2 (14.3)  
 Positive 69 (89.6) 25 (92.6) 13 (81.3) 19 (95.0) 12 (85.7)  
GDH (S)       0.350
 Negative 58 (75.3) 18 (66.7) 11 (68.8) 17 (85.0) 12 (85.7)  
 Positive 19 (24.7) 9 (33.3) 5 (31.3) 3 (15.0) 2 (14.3)  
ASCT2 (T)       0.413
 Negative 47 (61.0) 15 (55.6) 8 (50.0) 15 (75.0) 9 (64.3)  
 Positive 30 (39.0) 12 (44.4) 8 (50.0) 5 (25.0) 5 (35.7)  
ASCT2 (S)       0.313
 Negative 73 (94.8) 24 (88.9) 16 (100.0) 19 (95.0) 14 (100.0)  
 Positive 4 (5.2) 3 (11.1) 0 (0.0) 1 (5.0) 0 (0.0)  
ATP synthase (T)       0.597
 Negative 2 (2.6) 1 (3.7) 1 (6.3) 0 (0.0) 0 (0.0)  
 Positive 75 (97.4) 26 (96.3) 15 (93.8) 20 (100.0) 14 (100.0)  
ATP synthase (S)       0.101
 Negative 62 (80.5) 18 (66.7) 13 (81.3) 19 (95.0) 12 (85.7)  
 Positive 15 (19.5) 9 (33.3) 3 (18.8) 1 (5.0) 2 (14.3)  
SDHA (T)       0.208
 Negative 3 (3.9) 1 (3.7) 2 (12.5) 0 (0.0) 0 (0.0)  
 Positive 74 (96.1) 26 (96.3) 14 (87.5) 20 (100.0) 14 (100.0)  
SDHA (S)       0.200
 Negative 59 (76.6) 17 (63.0) 14 (87.5) 16 (80.0) 12 (85.7)  
 Positive 18 (23.4) 10 (37.0) 2 (12.5) 4 (20.0) 2 (14.3)  
SDHB (T)       0.112
 Negative 28 (36.4) 7 (25.9) 9 (56.3) 9 (45.0) 3 (21.4)  
 Positive 49 (63.6) 20 (74.1) 7 (43.8) 11 (55.0) 11 (78.6)  
SDHB (S)       0.025
 Negative 66 (85.7) 19 (70.4) 15 (93.8) 20 (100.0) 12 (85.7)  
 Positive 11 (14.3) 8 (29.6) 1 (6.3) 0 (0.0) 2 (14.3)  
  1. PD: poorly differentiated carcinoma, AD: adenocarcinoma, SQ: squamous cell carcinoma, UD: undifferentiated carcinoma.
  2. Bold represents p<0.05.