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Table 2 Distribution of GLV-1h68 virus particles in tissues of PC14PE6-RFP tumor-bearing nude mice treated with GLV-1h68 or GLV-1h68/CPA

From: Combination treatment with oncolytic Vaccinia virus and cyclophosphamide results in synergistic antitumor effects in human lung adenocarcinoma bearing mice

Distribution of GLV-1h68 in tissues of PC14PE6-RFP tumor-bearing nude mice, 21 dpi

Tissue

pfu/g of tissue (n = 3)

 

GLV-1h68-treated mice

GLV-1h68- and CPA-treated mice

Tumor

6.35×108+/-9.01×107 (3/3)

1.42×108+/-5.1×106 (3/3)

Liver

0

0

Spleen

0

0

Lungs

2.63×102+/-9.43 (1/3)

0

Ovaries

1.51×104+/-3.06×102 (2/3)

7.28×104+/-1.15×103 (1/3)

Brain

0

0

  1. PC14PE6-RFP tumor-bearing nude mice (n = 3) were either infected solely with 1×107 pfu of GLV-1h68 or infected with GLV-1h68 and received simultaneous treatment with CPA. 21 days after infection, tumors and organs were harvested and viral titers were determined by standard plaque assays on CV-1 cells. Results are shown as mean pfu/g tissue or organ +/- s.d.
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Journal of Translational Medicine

ISSN: 1479-5876

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