Figure 1

Pedigrees of families with BAG3 mutations: family DCM-1 - large deletion of exons 3–4, family DCM-15 - Gly379AlafsX45, family DCM-16 - Glu455Lys, family DCM-84 - Tyr451X, family DCM-71 - Glu455Lys, family DCM-18 - Gln353ArgfsX10. Squares represent males and circles represent females. An arrowhead denotes the proband. A diagonal line marks deceased individuals. Solid symbols denote dilated cardiomyopathy. Open symbols with asterisk denote unaffected individuals with clinically normal echo/ecg. Other features are shown in box below. The presence or absence of a BAG3 mutation is indicated by a + or − symbol, respectively; obligate carriers are noted in parenthesis (+).