Circulating N-terminal brain natriuretic peptide and cardiac function in response to acute systemic hypoxia in healthy humans

Table 1 Cardiac function at baseline and after 20 minutes exposure to hypoxic stimulus

	Baseline	Hypoxia
Cardiac output (L/min)	6.0 ± 1.2	8.1 ± 1.6***
Ejection fraction (%)	67 ± 4	75 ± 6***
RV ED diameter (mm)	25 ± 4	26 ± 3
RA diameter (mm)	20 ± 4	19 ± 2
LA diameter (mm)	39 ± 4	38 ± 3
PA blood flow velocity (m/s)	0.8 ± 0.1	1.0 ± 0.1*
Vena cava inferior (mm)	16.8 ± 4.6	15.2 ± 4.2
RV-to-RA pressure gradient (mmHg)	28 ± 5	31 ± 3*
RV E’/ A’ (cm/s)	1.5 ± 0.4	1.4 ± 0.2
RV S_m (cm/s)	0.20 ± 0.04	0.24 ± 0.04*
Pulmonary vein s/d ratio	1.3 ± 0.2	1.4 ± 0.3
TAPSE (cm)	2.6 ± 0.2	3.0 ± 0.3**
LAD diameter (cm)	5.62 ± 0.64	5.60 ± 0.64
LAD blood flow velocity (m/s)	0.16 ± 0.4	0.28 ± 0.07**
LV lateral wall E’/A’	1.9 ± 0.7	1.5 ± 0.6
LV septal wall E’/A’	1.6 ± 0.3	1.5 ± 0.3
LV septum S_m (cm/s)	0.12 ± 0.02	0.15 ± 0.05
LV lateral wall S_m (cm/s)	0.16 ± 0.06	0.19 ± 0.06
Lateral mitral annular displacement (cm)	1.5 ± 0.2	1.8 ± 0.2**
Septal mitral annular displacement (cm)	1.5 ± 0.1	1.7 ± 0.3*
E/A –ratio	1.6 ± 0.3	1.4 ± 0.2*

LV = left ventricle, RV = Right ventricle, LA = left atrium , RA = right atrium, TAPSE = Tricuspid annular plane systolic excursion, PA = pulmonary artery, E’ = tissue-Doppler early diastolic velocity, A’ = tissue-Doppler late diastolic velocity, S_m = tissue-Doppler systolic velocity, E = Mitral inflow early peak velocity, A = Mitral inflow atrial peak velocity. *p < 0.05, **p < 0.01, ***p < 0.001 compared to baseline. LAD = the left anterior descending coronary artery.

ISSN: 1479-5876