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Table 4 Effect of ursodeoxycholic acid (UDCA) administration on diet induced nonalcoholic fatty liver disease (NAFLD) activity score (NAS) and fibrosis score

From: Progression of diet induced nonalcoholic steatohepatitis is accompanied by increased expression of kruppel-like-factor 10 in mice

Age diet

48 SD†(n = 8)

48 HFSD‡(n = 8)

48 HFSD/UDCA (n = 8)

NAS§

0.00 ± 0.00

8.17 ± 0.40*

4.00 ± 0.44* , **

Fibrosis

0.00 ± 0.00

2.42 ± 0.08*

2.07 ± 0.53*

  1. Data are expressed as mean ± standard error (SE).
  2. †SD, standard chow is considered as standard diet.
  3. ‡HFSD, high fat and sucrose diet.
  4. §NAS, nonalcoholic fatty liver disease activity score, which is the summation of the pathologic scores for steatosis, inflammation and hepatic ballooning.
  5. *P < 0.05, when compared with mice given SD.
  6. **P < 0.05, when compared with mice given HFSD.
  7. Results with statistical significances are shown in bold letters.