Skip to main content
Figure 1 | Journal of Translational Medicine

Figure 1

From: Progression of diet induced nonalcoholic steatohepatitis is accompanied by increased expression of kruppel-like-factor 10 in mice

Figure 1

Changes in KLF10 and other associated gene expression in diet induced NASH. C57BL/6 mice were fed with high fat, sucrose diet (HFSD) and sacrificed at 12, 24, or 48 weeks after the feeding. Mice that were given standard diet (SD) for 12 weeks served as control. A, KLF10 mRNA expression in the liver of SD fed mice showed no significant changes according to their age when test at the age of 12, 24, and 48 weeks after SD feeding (P = 0.393). B, Significant up-regulation of KLF10 mRNA was observed by week 12 and thereafter when compared with the mice fed with SD which served as control (P = 0.003). Expression of Colα(I) mRNA significantly increased at week 24 and 48 (P = 0.004) when compared with that of mice fed with SD for 12 weeks. C, Significant increase of TGFβ mRNA was detected from week 24 and it progressed at week 48 (P = 0.001). Downstream Smad 2, and 3 also increased as fibrosis progressed although significant increase of Smad 2 (P = 0.003) and 3 (P = 0.042) were demonstrated as early as week 12. Inhibitory Smad7 increased from week 24 (P = 0.002). D, Expression of ChREBP which is reported to have a protective effect on insulin resistance, decreased with HFSD feeding, although the change was not related with either the duration of HFSD feeding or the severity of NASH (P = 0.023). Expression of a lipogenic gene, SREBP-1c showed no significant change with HFSD feeding (P = 0.167). *P < 0.05, when compared with that of mice fed with SD. **P < 0.05 when compared with that of mice fed with HFSD for the shorter duration.

Back to article page