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Table 5 Dataset HYP overlapping between murine and human vascular tissues across the V-IPN subnetworks

From: A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability

Mm_Ao_16w_ApoE_CS_vs_sham

Mm_Ao_78w_ApoE_vs_wt

Hs_athCA_vs_ctIMA

No of HYPs

EC activation

Platelet activation

EC-monocyte interaction

Foam cell formation

SMC activation

Plaque destabilization

X

X

X

18

11 (7)

3 (5)

2 (7)

8 (7)

9 (10)

9 (9)

X

X

-

8

2 (1)

0 (0)

0 (0)

4 (3)

3 (3)

1 (1)

X

-

X

6

2 (1)

0 (0)

2 (7)

3 (3)

2 (2)

4 (4)

-

X

X

32

18 (12)

6 (10)

5 (17)

15 (13)

4 (5)

16 (16)

X

-

-

20

9 (6)

5 (8)

0 (0)

8 (7)

5 (6)

4 (4)

-

X

-

51

28 (18)

2 (3)

6 (21)

15 (13)

16 (18)

17 (17)

-

-

X

24

11 (7)

8 (14)

2 (7)

10 (8)

5 (6)

8 (8)

-

-

-

583

73 (47)

36 (61)

12 (41)

55 (47)

43 (49)

44 (43)

  1. Numbers between parentheses are percentage of total number of possible HYPs.