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Table 4 Summary statistics of dataset overlapping across the six V-IPN subnetworks

From: A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability

 

Dataset name

Dataset ID

N° of state changes (SC)

N°of HYPs in dataset

NoHYPs overlapping withEC activation

N° HYPs overlapping withplatelet activation

N° HYPs overlapping withEC-monocyte interaction

N° HYPs overlapping withfoam cell formation

N° HYPs O/L with SMC Activation

N° HYPs O/L with Plaque Destabilization

N° HYPs O/L with V-IPN

Total N° of possible HYPs in each subnetwork for human/mouse

2410/ 2354

155/149

59/55

30/27

118/113

88/84

104/102

340*/334

Mouse

Mm_Ao_78w_ApoE_vs_wt

GSE10000

3872

449

59

11

13

42

32

43

110

Mm_Ao_16w_ApoE_CS_vs_sham

E-MTAB-1696

1928

245

24

8

4

23

19

18

52

Human

Hs_EC_GFP_oxLDL_vs_ct

GSE13139

398

152

16

4

4

16

9

14

31

Hs_EC_LOX1_oxLDL_vs_ct

GSE13139

752

224

30

8

8

21

16

21

52

Hs_EC_oxPAP_vs_ct

GSE20060

609

309

45

12

8

21

23

27

77

Hs_athCA_vs_ctIMA

GSE40231

3643

309

42

17

11

36

20

37

80

Hs_NHBE_CDKinh_rel_vs_blk_8h

E-MTAB-1272

1655

296

27

5

7

19

18

14

53

Hs_MVEC-C_hpx_vs_ct_24h

GSE11341

459

192

27

8

4

16

16

18

48

Hs_MVEC-L_hpx_vs_ct_24h

GSE11341

504

198

22

4

4

15

13

14

42

 

Hs_JurkT_ars_vs_ct

GSE46909

2381

157

15

5

3

3

9

8

31

  1. Reverse causal reasoning (RCR) analysis was conducted using richness and concordance p values <0.05. HYPs that met both criteria were considered to be statistically significant. *Total number of unique human HYPs among the six subnetworks. Total is not 551 HYPs, the sum obtained from Figure 3, due to node/HYP overlap between the subnetworks. Mm_Ao_78w_ApoE_vs_wt (GSE10000) is included in this table as a building dataset reference. O/L: overlapping. Dataset Name Dataset ID N° of state changes (SC) N° of HYPs in dataset N° HYPs O/L with EC Activation N° HYPs O/L with Platelet Activation N° HYPs O/L with EC-Monocyte Interaction N° HYPs O/L with Foam Cell Formation N° HYPs O/L with SMC Activation N° HYPs O/L with Plaque Destabilization N° HYPs O/L with V-IPN.
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Journal of Translational Medicine

ISSN: 1479-5876

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