|
Treatment
|
AZD
|
AZD
|
AZD + TMZ
|
AZD + TMZ
|
|---|
|
Timepoint:
|
48 h
|
72 h
|
48 h
|
72 h
|
|---|
|
Population:
|
All cells
|
Cyclin A2-
|
Cyclin A2+
|
All cells
|
Cyclin A2-
|
Cyclin A2+
|
All cells
|
Cyclin A2-
|
Cyclin A2+
|
All cells
|
Cyclin A2-
|
Cyclin A2+
|
|---|
|
Stain:
| | | | | | | | | | | | |
|
p-H2AX
|
0.536
|
0.119
|
0.012
|
0.558
|
0.151
|
0.039
|
0.673
|
0.172
|
0.014
|
0.509
|
0.272
|
0.011
|
|
p-RPA2
|
0.545
|
0.372
|
0.545
|
0.599
|
0.442
|
0.229
|
0.875
|
0.445
|
0.916
|
0.900
|
0.767
|
0.859
|
|
p-DNA-PKcs
|
0.398
|
0.419
|
0.957
|
0.597
|
0.469
|
0.336
|
0.776
|
0.952
|
0.894
|
0.758
|
0.562
|
0.297
|
|
p21
|
0.315
|
0.413
|
0.132
|
0.645
|
0.737
|
0.203
|
0.693
|
0.708
|
0.364
|
0.778
|
0.706
|
0.452
|
|
p-ATM
|
0.636
|
0.848
|
0.390
|
0.940
|
0.693
|
0.228
|
0.746
|
0.967
|
0.736
|
0.813
|
0.920
|
0.694
|
|
p-BRCA1
|
0.754
|
0.954
|
0.608
|
0.505
|
0.872
|
0.721
|
0.858
|
0.839
|
0.756
|
0.684
|
0.970
|
0.860
|
- Statistically significant p-values (p < .05) for stratifying BRCA1+/- vs. BRCA1+/+cell lines are shown in bold.
