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Table 1 Patient characteristics and laboratory values at baseline, 24W and 72W

From: HBsAg as an important predictor of HBeAg seroconversion following antiviral treatment for HBeAg-positive chronic hepatitis B patients

Characteristic

SC

Non-SC

 

Baseline

24W

72W

Baseline

24W

72W

Age (years)

29.8 ± 8.9

-

-

34.4 ± 9.1

-

-

Gender (M/F)

7/2

-

-

9/2

-

-

ALT (U/L)

240.2 ± 67.8a

29.7 ± 11.0

19.4 ± 9.0*

156.7 ± 41.9a

48.2 ± 23.4

48.6 ± 35.9▲

TBiL (μmol/L)#

19.3 ± 8.8a

14.4 ± 4.9

12.7 ± 4.7

13.1 ± 3.7a

14.4 ± 3.2

11.6 ± 4.3

ALB (g/L)#

44.3 ± 1.8

47.3 ± 2.7

47.3 ± 0.7

45.3 ± 2.1

48.3 ± 3.3

47.4 ± 3.2

HBV DNA (log10 cps/ml)§

8.91 ± 0.56

4.07 ± 1.32

2.1 ± 0.04

8.46 ± 0.73

4.06 ± 1.30

2.53 ± 0.50

HBsAg (log10 IU/ml)

4.15 ± 0.53

3.15 ± 0.25**

2.93 ± 0.42

3.86 ± 0.91

3.43 ± 0.73▲

3.16 ± 0.41

HBV genotype

5B, 4C

-

-

7B, 4C

-

-

  1. These values expressed as mean ± SD, unless otherwise indicated.
  2. Normal values: ALT, ≤ 48 U/L; TBiL, ≤ 22 μmol/L; ALB, 32 ~ 50 g/L.
  3. *P <0.05, comparing with week 24; **P <0.001, comparing with baseline; â–² P >0.05, comparing with baseline or week 24.
  4. § P <0.001, among SC or non-SC groups; #P >0.05, among SC or non-SC groups.
  5. a P <0.001, comparison between SC and non-SC groups at baseline.
  6. ALT, alanine transaminase; ALB, albumin; DNA, deoxyribonucleic acid; HBV, hepatitis B virus; TBiL, Total bilirubin; −, useless; non-SC, non HBeAg seroconversion; SC, HBeAg seroconversion.
  7. All subjects were of Chinese Han ethnicity.