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Figure 1 | Journal of Translational Medicine

Figure 1

From: Metallothionein III (MT3) is a putative tumor suppressor gene that is frequently inactivated in pediatric acute myeloid leukemia by promoter hypermethylation

Figure 1

Analysis of promoter methylation in pediatric AML by NimbleGen Human DNA Methylation arrays. Analysis of the methylation status of genes in five pediatric AML samples (L1, L2, L3, L4 and L5) and three NBM samples (N1, N2, and N3) using NimbleGen Human DNA Methylation arrays shows that the MT3 promoter is significantly methylated in AML samples (5/5) and unmethylated in NBM samples (1/3). (A) Each red box represents the number of methylation peaks (PeakScore) overlapping the promoter region for the corresponding gene. The PeakScore is defined as the average -log10 (P-value) from probes within the peak. (B) The scores reflect the probability of positive methylation enrichment.

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