Table 3 Pre-specified hypotheses for testing in the current study cohort
Hypothesis order | SCNP Node | Cell subset | Wilcoxon p-value | Hypothesis verified? |
|---|---|---|---|
1 | IL-2 → p-Stat5 | CD45RA+ Th cells | 1.10 × 10-8 | Yes |
2 | IFN-α → p-Stat5 | CD45RA+ cytotoxic T cells | 5.65 × 10-10 | Yes |
3 | IL-27 → p-Stat5 | CD45RA+ cytotoxic T cells | 9.38 × 10-11 | Yes |
4 | IFN-α → p-Stat1 | CD45RA+ cytotoxic T cells | 8.67 × 10-8 | Yes |
5 | IL-6 → p-Stat1 | CD45RA+ cytotoxic T cells | 2.46 × 10-9 | Yes |
6 | IL-4 → p-Stat6 | CD45RA+ cytotoxic T cells | 1.86 × 10-4 | Yes |
7 | IL-6 → p-Stat3 | CD45RA+ cytotoxic T cells | 6.70 × 10-7 | Yes |
8 | IFN-α → p-Stat5 | CD45RA+ Th cells | 5.28 × 10-6 | Yes |
9 | IL-27 → p-Stat1 | CD45RA+ cytotoxic T cells | 7.70 × 10-8 | Yes |
10 | IFN-α → p-Stat3 | CD45RA+ cytotoxic T cells | 0.180 | No |
11 | PMA → p-S6 | CD45RA+ cytotoxic T cells | 4.82 × 10-6 | No* |