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Table 2 Disease progression with regard to the TLR4 rs11536889 genotypes

From: The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients

 

All n = 210

GG n = 146

GC/CC n = 64

p value

SOFA

7.6 ± 4.5

7.9 ± 4.5

6.8 ± 4.2

0.0005

SOFA-Respiratory score

2.1 ± 1.1

2.1 ± 1.1

2.0 ± 1.1

0.1950

SOFA-Cardiovascular score

1.6 ± 1.5

1.7 ± 1.5

1.4 ± 1.4

0.1296

SOFA-Central nervous system score

2.0 ± 1.5

2.1 ± 1.5

1.9 ± 1.4

0.0802

SOFA-Renal score

0.9 ± 1.4

1.0 ± 1.4

0.7 ± 1.2

0.0005

SOFA-Coagulation score

0.3 ± 0.8

0.4 ± 0.8

0.3 ± 0.7

0.0245

SOFA-Hepatic score

0.3 ± 0.7

0.4 ± 0.8

0.2 ± 0.5

<0.0001

Mortality analysis, %:

    

Death at day 28

18

18

17

1.0000

Death at day 90

30

30

28

0.8698

Length of stay in ICU (days)

18 ± 16

18 ± 17

20 ± 14

0.0720

Organ support*, %

    

Mechanical ventilation

 

75

74

0.6286

Use of vasopressor

 

38

37

0.8426

Renal replacement therapy

 

14

9

0.4486

  1. The data are presented as the mean ± SD or percentages.
  2. *Based on the total number of observations in follow-up days.