The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients

Table 2 Disease progression with regard to the TLR4 rs11536889 genotypes

	All n = 210	GG n = 146	GC/CC n = 64	p value
SOFA	7.6 ± 4.5	7.9 ± 4.5	6.8 ± 4.2	0.0005
SOFA-Respiratory score	2.1 ± 1.1	2.1 ± 1.1	2.0 ± 1.1	0.1950
SOFA-Cardiovascular score	1.6 ± 1.5	1.7 ± 1.5	1.4 ± 1.4	0.1296
SOFA-Central nervous system score	2.0 ± 1.5	2.1 ± 1.5	1.9 ± 1.4	0.0802
SOFA-Renal score	0.9 ± 1.4	1.0 ± 1.4	0.7 ± 1.2	0.0005
SOFA-Coagulation score	0.3 ± 0.8	0.4 ± 0.8	0.3 ± 0.7	0.0245
SOFA-Hepatic score	0.3 ± 0.7	0.4 ± 0.8	0.2 ± 0.5	<0.0001
Mortality analysis, %:
Death at day 28	18	18	17	1.0000
Death at day 90	30	30	28	0.8698
Length of stay in ICU (days)	18 ± 16	18 ± 17	20 ± 14	0.0720
Organ support^*, %
Mechanical ventilation		75	74	0.6286
Use of vasopressor		38	37	0.8426
Renal replacement therapy		14	9	0.4486