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Table 2 Disease progression with regard to the TLR4 rs11536889 genotypes

From: The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients

  All n = 210 GG n = 146 GC/CC n = 64 p value
SOFA 7.6 ± 4.5 7.9 ± 4.5 6.8 ± 4.2 0.0005
SOFA-Respiratory score 2.1 ± 1.1 2.1 ± 1.1 2.0 ± 1.1 0.1950
SOFA-Cardiovascular score 1.6 ± 1.5 1.7 ± 1.5 1.4 ± 1.4 0.1296
SOFA-Central nervous system score 2.0 ± 1.5 2.1 ± 1.5 1.9 ± 1.4 0.0802
SOFA-Renal score 0.9 ± 1.4 1.0 ± 1.4 0.7 ± 1.2 0.0005
SOFA-Coagulation score 0.3 ± 0.8 0.4 ± 0.8 0.3 ± 0.7 0.0245
SOFA-Hepatic score 0.3 ± 0.7 0.4 ± 0.8 0.2 ± 0.5 <0.0001
Mortality analysis, %:     
Death at day 28 18 18 17 1.0000
Death at day 90 30 30 28 0.8698
Length of stay in ICU (days) 18 ± 16 18 ± 17 20 ± 14 0.0720
Organ support*, %     
Mechanical ventilation   75 74 0.6286
Use of vasopressor   38 37 0.8426
Renal replacement therapy   14 9 0.4486
  1. The data are presented as the mean ± SD or percentages.
  2. *Based on the total number of observations in follow-up days.