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Table 1 Patient baseline characteristics with regard to the TLR4 rs11536889 genotypes

From: The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients

  All n = 210 GG n = 146 GC/CC n = 64 p value
Age [years] 63 ± 15 63 ± 16 63 ± 15 0.9116
Male, % 64% 46% 58% 0.2752
Body-mass index, mean ± SD 28 ± 9 28 ± 7 30 ± 13 0.1507
Severity of sepsis 48% 46% 52% 0.4576
Sepsis/severe sepsis, % 52% 54% 48%  
Septic shock, %    
SOFA score, mean ± SD 8.6 ± 4.1 8.9 ± 4.3 8.0 ± 3.7 0.2449
APACHE II score, mean ± SD 21.3 ± 7.4 21.6 ± 7.4 20.6 ± 7.6 0.4053
Comorbidities, %     
Hypertension   58 59 1.0000
History of myocardial infarction   5 6 0.7586
COPD   18 17 1.0000
Renal dysfunction   11 20 0.0834
Diabetes mellitus (NIDDM)   11 8 0.6202
Diabetes mellitus (IDDM)   11 5 0.1938
Chronic liver diseases   7 9 0.7839
History of cancer   18 19 0.8481
History of stroke   6 8 0.7647
Recent surgical history, %     0.0631
Elective surgery 28 31 19  
Emergency surgery 44 44 44  
No history of surgery 28 24 37  
Site of infection, %     0.1516
Lung 50 46 56  
Abdomen 30 31 28  
Bone or soft tissue 7 7 6  
Surgical wound 2 3 0  
Urogenital 1 0 3  
Primary bacteremia 6 7 3  
Other 4 5 3  
Organ support, %     
Mechanical ventilation 83 83 83 0.8933
Use of vasopressor 52 54 48 0.4576
Renal-replacement therapy 10 11 9 0.7300
  1. The data are presented as the mean ± SD or percentages.