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Table 1 Patient baseline characteristics with regard to the TLR4 rs11536889 genotypes

From: The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients

 

All n = 210

GG n = 146

GC/CC n = 64

p value

Age [years]

63 ± 15

63 ± 16

63 ± 15

0.9116

Male, %

64%

46%

58%

0.2752

Body-mass index, mean ± SD

28 ± 9

28 ± 7

30 ± 13

0.1507

Severity of sepsis

48%

46%

52%

0.4576

Sepsis/severe sepsis, %

52%

54%

48%

 

Septic shock, %

   

SOFA score, mean ± SD

8.6 ± 4.1

8.9 ± 4.3

8.0 ± 3.7

0.2449

APACHE II score, mean ± SD

21.3 ± 7.4

21.6 ± 7.4

20.6 ± 7.6

0.4053

Comorbidities, %

    

Hypertension

 

58

59

1.0000

History of myocardial infarction

 

5

6

0.7586

COPD

 

18

17

1.0000

Renal dysfunction

 

11

20

0.0834

Diabetes mellitus (NIDDM)

 

11

8

0.6202

Diabetes mellitus (IDDM)

 

11

5

0.1938

Chronic liver diseases

 

7

9

0.7839

History of cancer

 

18

19

0.8481

History of stroke

 

6

8

0.7647

Recent surgical history, %

   

0.0631

Elective surgery

28

31

19

 

Emergency surgery

44

44

44

 

No history of surgery

28

24

37

 

Site of infection, %

   

0.1516

Lung

50

46

56

 

Abdomen

30

31

28

 

Bone or soft tissue

7

7

6

 

Surgical wound

2

3

0

 

Urogenital

1

0

3

 

Primary bacteremia

6

7

3

 

Other

4

5

3

 

Organ support, %

    

Mechanical ventilation

83

83

83

0.8933

Use of vasopressor

52

54

48

0.4576

Renal-replacement therapy

10

11

9

0.7300

  1. The data are presented as the mean ± SD or percentages.