Figure 4

Top panel: Kaplan-Meier analysis of the time to development of metastases of the two groups (groups A and B) and the four groups (groups 1–4) of UPS samples, defined by the first and second break points of the hierarchical clustering with the RCC-gene set. The time to development of metastasis differed between groups A and B, p = 0.0002 and groups 1–4, p < 0.0007 (see Additional file 1: Table S1). Second row: Kaplan-Meier analysis of the time to development of metastases of the two (groups A and B) and four groups (groups 1–4) of UPS samples defined by the first and second break points, respectively, of the hierarchical clustering with the AF-gene set. The time to development of metastasis differed between groups A and B, p = 0.0007, and groups 1–4, p = 0.008 (see Additional file 1: Table S1). Third row: Kaplan-Meier analysis of the time to development of metastases of the two groups (groups A and B), and five groups (groups 1–5) of the UPS samples, defined by the first break point, and visual separation of the break points, respectively, of the hierarchical clustering with the OVCA-gene set. The time to development of metastasis differed between groups A and B, p = 0.004, and between groups 1–5, p = 0.0009 (see Additional file 1: Table S1). Bottom row: Kaplan-Meier analysis of the time to development of metastases of the four groups of LipoD samples defined by the second break points of the hierarchical clustering with the AF-gene set, p = 0.011 (see Additional file 1: Table S1).