Skip to main content

Advertisement

Table 1 Clinico-pathological variables and the expression of miR-200b in total breast cancer patients

From: miR-200b as a prognostic factor in breast cancer targets multiple members of RAB family

Characteristics Total (n = 134) miR-200b low (n = 78) miR-200b high (n = 56) P value
No. % No. %
Age (years)       0.330
<50 82 46 56.1 36 43.9  
>50 52 32 61.5 20 38.5  
Menopause       0.524
Yes 63 37 58.7 26 41.3  
No 71 41 57.7 30 42.3  
LN infiltrated       0.148
Yes 80 50 62.5 30 37.5  
No 54 28 51.9 26 48.1  
Tumor size (cm)       0.080
= < 2 38 18 47.3 20 52.7  
>2 96 60 62.5 36 37.5  
TNM stage       0.040*
I-II 78 40 51.3 38 48.7  
III- IV 56 38 67.9 18 32.1  
Local relapse       0.083
Yes 8 7 87.5 1 12.5  
No 126 71 56.3 55 43.7  
Distant metastasis       0.003*
Yes 34 27 79.4 7 20.6  
No 100 51 61.0 49 49.0  
ER status       0.155
Positive 51 33 64.7 18 35.3  
Negative 83 45 54.2 38 45.8  
PR status       0.073
Positive 54 36 66.7 18 33.3  
Negative 80 42 52.5 38 47.5  
HER-2 status       0.213
Positive 22 15 68.2 7 31.8  
Negative 112 63 56.3 49 43.8  
TNBC status       0.472
TNBC 51 29 56.9 22 43.1  
Non-TNBC 83 49 59.0 34 41.0  
  1. *means statistically significant (p < 0.05).
  2. % means percentage within the row.
  3. TNBC, triple-negative breast cancer, means ER(-), PR(-), HER-2(-). High expression of miR-200b was seen in 41.8% of total patients and correlated with early TNM stage (p = 0.040) and fewer metastasis (p = 0.003).