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Figure 5 | Journal of Translational Medicine

Figure 5

From: miR-200b as a prognostic factor in breast cancer targets multiple members of RAB family

Figure 5

Over-expression of miR-200b or knock-down of RAB21, RAB23, RAB18 and RAB3B inhibits breast cancer cell proliferation and invasion. (A) Transfection of miR-200b mimics or knock-down of RAB21, RAB23, RAB18 and RAB3B in MDA-MB-231 and 4 T1 cells markedly attenuated cell proliferation: MTT assay at 24 h, 48 h and 72 h after transfection. (B, C) Transfection of miR-200b mimics or knock-down of RAB21, RAB23, RAB18 and RAB3B in MDA-MB-231 and 4 T1 cells inhibited cell invasion: Data shown in Figure B were the mean ± s.d. of three replicates and were representative of three independent experiments. *P < 0.05. The representing images were shown in Figure C.

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