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Table 2 The major perturbed pathways in combination comparing with other three groups respectively

From: Sequential combination of decitabine and idarubicin synergistically enhances anti-leukemia effect followed by demethylating Wnt pathway inhibitor promoters and downregulating Wnt pathway nuclear target

Groups Pathways Hits Total Percent p value
Combination vs. control (p < 0.001) MAPK signaling pathway 42 271 15.5% 0.0
  TGF-beta signaling pathway 17 85 20.0% 0.0
  Natural killer cell mediated cytotoxicity 23 141 16.31% 0.0
  VEGF signaling pathway 9 76 11.84% 0.0147
  Wnt signaling pathway 18 151 11.92% 7.0E-4
Combination vs. DAC (p < 0.05) MAPK signaling pathway 8 271 2.95% 0.0318
  p53 signaling pathway 3 69 4.35% 0.0689
  TGF-beta signaling pathway 4 85 4.71% 0.0298
  Wnt signaling pathway 9 151 5.96% 3.0E-4
Combination vs. IDA (p < 0.05) MAPK signaling pathway 21 271 7.75% 8.0E-4
  Natural killer cell mediated cytotoxicity 19 141 13.48% 0.0
  p53 signaling pathway 9 69 13.04% 0.0011
  PPAR signaling pathway 7 69 10.14% 0.0128
  TGF-beta signaling pathway 12 85 14.12% 1.0E-4
  Wnt signaling pathway 16 151 10.6% 1.0E-4