Ecto-protein kinases and phosphatases: an emerging field for translational medicine

Table 2 Extracellular phosphorylation in different diseases

Disease	Kinase	Protein	Effect	Reference
Alzheimer’s disease	ecto-PKA	amyloid-β-peptides	enhanced aggregation of amyloid-β-peptides	[41]
Prostate cancer	cAMP-dependent PKA			[44]
Breast cancer	cAMP-dependent PKC			[11]
Schizophrenia		72 proteins		[45]
Thrombosis and atherosclerosis		F11R aka JAM-A		[46]
Raine syndrome	FAM20C	SIBLINGs		[7]
Amelogenesis imperfecta	FAM20C	enamelin	calcium binding affected	[47]
Bacterial infection	PKC			[48]
Parasite infection	PKC, CK2			[49, 50]
HIV	ectophosphatase			[51]
Memory formation	ecto-PKC			[26]

ISSN: 1479-5876