Metabolomics of Ramadan fasting: an opportunity for the controlled study of physiological responses to food intake

Table 2 Metabolites that display significant differences between week 4 and week 1 of Ramadan

Metabolite	N	Fold change	p-value	Test	Significance
PC aa C36:6	16	1.221	9.2x10⁻⁵	Wilcoxon	Bonf
Histamine	16	−1.028	0.0031	Wilcoxon	FDR
PC ae C38:0	16	1.154	0.0063	Wilcoxon	FDR
PC aa C36:0	16	1.121	0.0076	Wilcoxon	FDR
Serotonin	16	1.109	0.0083	Mixed model	FDR
SM C26:1	16	1.182	0.0086	Mixed model	sig
C3-DC (C4-OH)	16	−1.269	0.010	Mixed model	sig
PC aa C36:1	16	1.193	0.013	Mixed model	sig
PC aa C28:1	16	1.087	0.022	Mixed model	sig
C16:2-OH	16	−1.143	0.026	Mixed model	sig
PC ae C32:2	16	1.089	0.031	Mixed model	sig
Chenodeoxycholic acid	16	2.014	0.031	Mixed model	sig
PC ae C40:6	16	1.083	0.039	Wilcoxon	sig
PC ae C38:2	16	1.116	0.040	Mixed model	sig
PC ae C38:1	16	1.203	0.040	Mixed model	sig
Ursodeoxycholic acid	15	−1.905	0.043	Mixed model	sig
PC ae C36:0	16	1.094	0.044	Mixed model	sig
PC aa C38:3	16	1.107	0.046	Mixed model	sig
PC ae C34:0	16	1.108	0.046	Mixed model	sig
SM (OH) C16:1	16	1.080	0.050	Mixed model	sig

Fold change is the ratio between the metabolite concentrations observed at both time points of week 4 and week 1, based on the estimate of the mixed model (see Table 1 for full legend).

ISSN: 1479-5876